Pregnancy-specific stress, fetoplacental haemodynamics, and neonatal outcomes in women with small for gestational age pregnancies: a secondary analysis of the multicentre Prospective Observational Trial to Optimise Paediatric Health in Intrauterine Growth Restriction.

Hdl Handle:
http://hdl.handle.net/10147/622946
Title:
Pregnancy-specific stress, fetoplacental haemodynamics, and neonatal outcomes in women with small for gestational age pregnancies: a secondary analysis of the multicentre Prospective Observational Trial to Optimise Paediatric Health in Intrauterine Growth Restriction.
Authors:
Levine, Terri A; Grunau, Ruth E; Segurado, Ricardo; Daly, Sean; Geary, Michael P; Kennelly, Mairead M; O'Donoghue, Keelin; Hunter, Alyson; Morrison, John J; Burke, Gerard; Dicker, Patrick; Tully, Elizabeth C; Malone, Fergal D; Alderdice, Fiona A; McAuliffe, Fionnuala M
Citation:
Pregnancy-specific stress, fetoplacental haemodynamics, and neonatal outcomes in women with small for gestational age pregnancies: a secondary analysis of the multicentre Prospective Observational Trial to Optimise Paediatric Health in Intrauterine Growth Restriction. 2017, 7 (6):e015326 BMJ Open
Publisher:
BMJ Open
Journal:
BMJ open
Issue Date:
21-Jun-2017
URI:
http://hdl.handle.net/10147/622946
DOI:
10.1136/bmjopen-2016-015326
PubMed ID:
28637734
Abstract:
To examine associations between maternal pregnancy-specific stress and umbilical (UA PI) and middle cerebral artery pulsatility indices (MCA PI), cerebroplacental ratio, absent end diastolic flow (AEDF), birthweight, prematurity, neonatal intensive care unit admission and adverse obstetric outcomes in women with small for gestational age pregnancies. It was hypothesised that maternal pregnancy-specific stress would be associated with fetoplacental haemodynamics and neonatal outcomes.; This is a secondary analysis of data collected for a large-scale prospective observational study.; This study was conducted in the seven major obstetric hospitals in Ireland and Northern Ireland.; Participants included 331 women who participated in the Prospective Observational Trial to Optimise Paediatric Health in Intrauterine Growth Restriction. Women with singleton pregnancies between 24 and 36 weeks gestation, estimated fetal weight <10th percentile and no major structural or chromosomal abnormalities were included.; Serial Doppler ultrasound examinations of the umbilical and middle cerebral arteries between 20 and 42 weeks gestation, Pregnancy Distress Questionnaire (PDQ) scores between 23 and 40 weeks gestation and neonatal outcomes.; Concerns about physical symptoms and body image at 35-40 weeks were associated with lower odds of abnormal UAPI (OR 0.826, 95% CI 0.696 to 0.979, p=0.028). PDQ score (OR 1.073, 95% CI 1.012 to 1.137, p=0.017), concerns about birth and the baby (OR 1.143, 95% CI 1.037 to 1.260, p=0.007) and concerns about physical symptoms and body image (OR 1.283, 95% CI 1.070 to 1.538, p=0.007) at 29-34 weeks were associated with higher odds of abnormal MCA PI. Concerns about birth and the baby at 29-34 weeks (OR 1.202, 95% CI 1.018 to 1.421, p=0.030) were associated with higher odds of AEDF. Concerns about physical symptoms and body image at 35-40 weeks were associated with decreased odds of neonatal intensive care unit admission (OR 0.635, 95% CI 0.435 to 0.927, p=0.019).; These findings suggest that fetoplacental haemodynamics may be a mechanistic link between maternal prenatal stress and fetal and neonatal well-being, but additional research is required.
Item Type:
Article
Language:
en
Description:
To examine associations between maternal pregnancy-specific stress and umbilical (UA PI) and middle cerebral artery pulsatility indices (MCA PI), cerebroplacental ratio, absent end diastolic flow (AEDF), birthweight, prematurity, neonatal intensive care unit admission and adverse obstetric outcomes in women with small for gestational age pregnancies. It was hypothesised that maternal pregnancy-specific stress would be associated with fetoplacental haemodynamics and neonatal outcomes
Keywords:
PREGNANCY; STRESS
Local subject classification:
FETAL GROWTH; PREGNANCY OUTCOME
MeSH:
Adult; Birth Weight; Body Image; Female; Fetal Growth Retardation; Gestational Age; Hemodynamics; Humans; Infant, Small for Gestational Age; Intensive Care, Neonatal; Middle Cerebral Artery; Parturition; Placental Circulation; Pregnancy; Premature Birth; Prospective Studies; Stress, Psychological; Surveys and Questionnaires; Ultrasonography, Doppler; Ultrasonography, Prenatal; Umbilical Arteries; Young Adult
ISSN:
2044-6055

Full metadata record

DC FieldValue Language
dc.contributor.authorLevine, Terri Aen
dc.contributor.authorGrunau, Ruth Een
dc.contributor.authorSegurado, Ricardoen
dc.contributor.authorDaly, Seanen
dc.contributor.authorGeary, Michael Pen
dc.contributor.authorKennelly, Mairead Men
dc.contributor.authorO'Donoghue, Keelinen
dc.contributor.authorHunter, Alysonen
dc.contributor.authorMorrison, John Jen
dc.contributor.authorBurke, Gerarden
dc.contributor.authorDicker, Patricken
dc.contributor.authorTully, Elizabeth Cen
dc.contributor.authorMalone, Fergal Den
dc.contributor.authorAlderdice, Fiona Aen
dc.contributor.authorMcAuliffe, Fionnuala Men
dc.date.accessioned2018-04-16T08:55:38Z-
dc.date.available2018-04-16T08:55:38Z-
dc.date.issued2017-06-21-
dc.identifier.citationPregnancy-specific stress, fetoplacental haemodynamics, and neonatal outcomes in women with small for gestational age pregnancies: a secondary analysis of the multicentre Prospective Observational Trial to Optimise Paediatric Health in Intrauterine Growth Restriction. 2017, 7 (6):e015326 BMJ Openen
dc.identifier.issn2044-6055-
dc.identifier.pmid28637734-
dc.identifier.doi10.1136/bmjopen-2016-015326-
dc.identifier.urihttp://hdl.handle.net/10147/622946-
dc.descriptionTo examine associations between maternal pregnancy-specific stress and umbilical (UA PI) and middle cerebral artery pulsatility indices (MCA PI), cerebroplacental ratio, absent end diastolic flow (AEDF), birthweight, prematurity, neonatal intensive care unit admission and adverse obstetric outcomes in women with small for gestational age pregnancies. It was hypothesised that maternal pregnancy-specific stress would be associated with fetoplacental haemodynamics and neonatal outcomesen
dc.description.abstractTo examine associations between maternal pregnancy-specific stress and umbilical (UA PI) and middle cerebral artery pulsatility indices (MCA PI), cerebroplacental ratio, absent end diastolic flow (AEDF), birthweight, prematurity, neonatal intensive care unit admission and adverse obstetric outcomes in women with small for gestational age pregnancies. It was hypothesised that maternal pregnancy-specific stress would be associated with fetoplacental haemodynamics and neonatal outcomes.-
dc.description.abstractThis is a secondary analysis of data collected for a large-scale prospective observational study.-
dc.description.abstractThis study was conducted in the seven major obstetric hospitals in Ireland and Northern Ireland.-
dc.description.abstractParticipants included 331 women who participated in the Prospective Observational Trial to Optimise Paediatric Health in Intrauterine Growth Restriction. Women with singleton pregnancies between 24 and 36 weeks gestation, estimated fetal weight <10th percentile and no major structural or chromosomal abnormalities were included.-
dc.description.abstractSerial Doppler ultrasound examinations of the umbilical and middle cerebral arteries between 20 and 42 weeks gestation, Pregnancy Distress Questionnaire (PDQ) scores between 23 and 40 weeks gestation and neonatal outcomes.-
dc.description.abstractConcerns about physical symptoms and body image at 35-40 weeks were associated with lower odds of abnormal UAPI (OR 0.826, 95% CI 0.696 to 0.979, p=0.028). PDQ score (OR 1.073, 95% CI 1.012 to 1.137, p=0.017), concerns about birth and the baby (OR 1.143, 95% CI 1.037 to 1.260, p=0.007) and concerns about physical symptoms and body image (OR 1.283, 95% CI 1.070 to 1.538, p=0.007) at 29-34 weeks were associated with higher odds of abnormal MCA PI. Concerns about birth and the baby at 29-34 weeks (OR 1.202, 95% CI 1.018 to 1.421, p=0.030) were associated with higher odds of AEDF. Concerns about physical symptoms and body image at 35-40 weeks were associated with decreased odds of neonatal intensive care unit admission (OR 0.635, 95% CI 0.435 to 0.927, p=0.019).-
dc.description.abstractThese findings suggest that fetoplacental haemodynamics may be a mechanistic link between maternal prenatal stress and fetal and neonatal well-being, but additional research is required.-
dc.language.isoenen
dc.publisherBMJ Openen
dc.rightsArchived with thanks to BMJ openen
dc.subjectPREGNANCYen
dc.subjectSTRESSen
dc.subject.meshAdult-
dc.subject.meshBirth Weight-
dc.subject.meshBody Image-
dc.subject.meshFemale-
dc.subject.meshFetal Growth Retardation-
dc.subject.meshGestational Age-
dc.subject.meshHemodynamics-
dc.subject.meshHumans-
dc.subject.meshInfant, Small for Gestational Age-
dc.subject.meshIntensive Care, Neonatal-
dc.subject.meshMiddle Cerebral Artery-
dc.subject.meshParturition-
dc.subject.meshPlacental Circulation-
dc.subject.meshPregnancy-
dc.subject.meshPremature Birth-
dc.subject.meshProspective Studies-
dc.subject.meshStress, Psychological-
dc.subject.meshSurveys and Questionnaires-
dc.subject.meshUltrasonography, Doppler-
dc.subject.meshUltrasonography, Prenatal-
dc.subject.meshUmbilical Arteries-
dc.subject.meshYoung Adult-
dc.subject.otherFETAL GROWTHen
dc.subject.otherPREGNANCY OUTCOMEen
dc.titlePregnancy-specific stress, fetoplacental haemodynamics, and neonatal outcomes in women with small for gestational age pregnancies: a secondary analysis of the multicentre Prospective Observational Trial to Optimise Paediatric Health in Intrauterine Growth Restriction.en
dc.typeArticleen
dc.identifier.journalBMJ openen

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