Acquired Factor Xiii Deficiency: An Uncommon But Easily Missed Cause Of Severe Bleeding

Hdl Handle:
http://hdl.handle.net/10147/623062
Title:
Acquired Factor Xiii Deficiency: An Uncommon But Easily Missed Cause Of Severe Bleeding
Authors:
Fogarty, H; Byrne, M; O’Connell, NM; Ryan, K; White, B; O’Donnell, JS; Lavin, M
Publisher:
Irish Medical Journal
Journal:
Irish Medical Journal
Issue Date:
May-2018
URI:
http://hdl.handle.net/10147/623062
Abstract:
Factor XIII (FXIII) is a plasma clotting protein involved in clot stabilization. Severe FXIII deficiency may present with severe, even fatal bleeding. Critically however, routine coagulation assays may be normal and only specific FXIII assays will detect the abnormality. Herein we discuss a case report of a patient with acquired FXIII deficiency in order to highlight the clinical challenges associated with establishing the diagnosis and discuss the treatment approach. A 70-year-old man presented with a gluteal haematoma despite no preceding personal history of bleeding. Extensive initial haemostatic investigations were normal until a specific FXIII assay showed a marked reduction in FXIII levels. With directed treatment, bleeding episodes ceased and remission was achieved. Clinical awareness of FXIII deficiency is important, so appropriate testing can be implemented in patients with unexplained bleeding diatheses, particularly those in whom bleeding responds poorly to standard replacement therapy.
Item Type:
Article
Language:
en
Keywords:
DEFICIENCY; BLOOD
Local subject classification:
PLASMA

Full metadata record

DC FieldValue Language
dc.contributor.authorFogarty, Hen
dc.contributor.authorByrne, Men
dc.contributor.authorO’Connell, NMen
dc.contributor.authorRyan, Ken
dc.contributor.authorWhite, Ben
dc.contributor.authorO’Donnell, JSen
dc.contributor.authorLavin, Men
dc.date.accessioned2018-06-12T10:56:40Z-
dc.date.available2018-06-12T10:56:40Z-
dc.date.issued2018-05-
dc.identifier.urihttp://hdl.handle.net/10147/623062-
dc.description.abstractFactor XIII (FXIII) is a plasma clotting protein involved in clot stabilization. Severe FXIII deficiency may present with severe, even fatal bleeding. Critically however, routine coagulation assays may be normal and only specific FXIII assays will detect the abnormality. Herein we discuss a case report of a patient with acquired FXIII deficiency in order to highlight the clinical challenges associated with establishing the diagnosis and discuss the treatment approach. A 70-year-old man presented with a gluteal haematoma despite no preceding personal history of bleeding. Extensive initial haemostatic investigations were normal until a specific FXIII assay showed a marked reduction in FXIII levels. With directed treatment, bleeding episodes ceased and remission was achieved. Clinical awareness of FXIII deficiency is important, so appropriate testing can be implemented in patients with unexplained bleeding diatheses, particularly those in whom bleeding responds poorly to standard replacement therapy.en
dc.language.isoenen
dc.publisherIrish Medical Journalen
dc.subjectDEFICIENCYen
dc.subjectBLOODen
dc.subject.otherPLASMAen
dc.titleAcquired Factor Xiii Deficiency: An Uncommon But Easily Missed Cause Of Severe Bleedingen
dc.typeArticleen
dc.identifier.journalIrish Medical Journalen
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
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