Ireland's central source for Open Access health research
Lenus, the Irish Health Research repository is the leading source for Irish research in health and social care. The Lenus collections include peer reviewed journal articles, grey literature, dissertations, reports and conference presentations. Lenus contains the publications of the Irish Health Service Executive (HSE) and the collected research output of over 130 health organisations past and present are all freely accessible.
If you are an Irish researcher or have conducted research in an Irish institution or health organisation, you can add your published research to Lenus. Submitted articles must be available in Open Access format or the publisher's policy must permit author self archiving. Advice on Open Access publishing and publishers' policies is available on the 'Open Access Publishing Guide' and 'Publishers' policies' pages available on the left-hand menu.
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HSE Open Access Research Awards 2019
This year’s awards were presented on Wednesday 4th December 2019. The winners are:
Des Crowley and colleagues: “Evaluating peer-supported screening as a hepatitis C case-finding model in prisoners”.
Acute Hospitals category:
George Shorten, Karthikeyan Srinivasan and colleagues: “Proficiency-based progression training: an ‘end to end’ model for decreasing error applied to achievement of effective epidural analgesia during labour: a randomised control study”.
Clinical Strategy and Programmes category:
Ide Delargy and colleagues: “Twenty years of the methadone treatment protocol in Ireland: reflections on the role of general practice”.
Primary Care category:
Conor Judge and colleagues: “Aspirin for primary prevention of stroke in individuals without cardiovascular disease—A meta-analysis”.
Mental Health category:
Quality Improvement category:
Daniela Rohde and colleagues: “Cognitive impairment and medication adherence post-stroke: A five-year follow-up of the ASPIRE-S cohort”.
Social Care category:
Natalie Hession and colleagues: “Being “Mindful” of Dignity in Dying: Developing Awareness, Fostering a Psychological Understanding, and Supporting Dignified Endings-To-Life”.
Health and Wellbeing category:
Congratulations to all the winners, and thanks to all those who took part.
Communities in Lenus
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Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent infection.Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination or vegetative growth. We hypothesised that loss of gut microbiota-derived bile salt hydrolases (BSHs) predisposes to CDI by perturbing gut bile metabolism, and that BSH restitution is a key mediator of FMT's efficacy in treating the condition.
Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis.PsA synovial tissue infiltrating CD4+ T-cells expressed higher levels of interleukin (IL)-17A, interferon gamma (IFN-γ), GM-CSF and CD161, with parallel enrichment of Th1, Th17 and exTh17 T-helper subsets (all p<0.05). Interestingly, a significant proportion of synovial T-cell subsets were triple-positive for GM-CSF, tumour necrosis factor (-TNF), -IL-17 or IFN-γ compared with matched blood (all p<0.05). Importantly, frequencies of polyfunctional T-cells correlated with DAPSA: Th1-GM-CSF+/TNF+/IFN-γ+ (r=0.7, p<0.01), Th17-GM-CSF+/TNF+/IL-17+ (r=0.6, p<0.057) and exTh17-GM-CSF+/TNF+/IFN-γ+ (r=0.7, p=0.0096), with no associations observed for single cytokine-producing T-cells. Following ex vivo culture of PsA synovial tissue cell suspensions, polyfunctional GM-CSF+TNFα+IL-17A+ or/IFN-γ+-producing T-cells (p<0.05), but not single cytokine-producing T-cells, were inhibited with a PDE4 inhibitor. Conclusion: These data demonstrate enrichment of polyfunctional T-cells in PsA synovial tissue which were strongly associated with DAPSA and ex vivo therapeutic response.