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Genetically distinct subsets within ANCA-associated vasculitis.Lyons, Paul A; Rayner, Tim F; Trivedi, Sapna; Holle, Julia U; Watts, Richard A; Jayne, David R W; Baslund, Bo; Brenchley, Paul; Bruchfeld, Annette; Chaudhry, Afzal N; et al. (The New England journal of medicine, 2012-07-19)Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a severe condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis) and microscopic polyangiitis. Its cause is unknown, and there is debate about whether it is a single disease entity and what role ANCA plays in its pathogenesis. We investigated its genetic basis.