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Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures.Ultaigh, Sinéad Nic An; Saber, Tajvur P; McCormick, Jennifer; Connolly, Mary; Dellacasagrande, Jerome; Keogh, Brian; McCormack, William; Reilly, Mary; O'Neill, Luke A; McGuirk, Peter; et al. (2011)The aim of this study was to examine the effect of blocking Toll-like receptor 2 (TLR2) in rheumatoid arthritis (RA) synovial cells.
Psoriatic arthritis management update - biotherapeutic options.Saber, Tajvur P; Veale, Douglas J; Centre for Arthritis Research and Education, Dublin Academic Health Care, St., Vincent's University Hospital, Elm Park, Dublin 4, Ireland. (2012-02-01)Psoriatic arthritis (PsA) is a seronegative spondyloarthropathy (SpA) occurring in up to 30% of patients with psoriasis. It has a wide variation of annual incidence (median 6.4, range 0.1-3.1 per 10(5) people), based on analysis of 13 incidence and prevalence reviews published between 1987 and December 2006. Conventional treatments with antiinflammatory and disease modifying or antirheumatic drugs are not efficacious in all patients, in particular those with axial disease. This review examines new pharmacological developments in the treatment of PsA with a focus on biologic therapies.