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Multimodal treatment of perianal fistulas in Crohn's disease: seton versus anti-TNF versus advancement plasty (PISA): study protocol for a randomized controlled trial.de Groof, E Joline; Buskens, Christianne J; Ponsioen, Cyriel Y; Dijkgraaf, Marcel G W; D'Haens, Geert R A M; Srivastava, Nidhi; van Acker, Gijs J D; Jansen, Jeroen M; Gerhards, Michael F; Dijkstra, Gerard; et al. (BioMed Central, 2015-08-20)Currently there is no guideline for the treatment of patients with Crohn's disease and high perianal fistulas. Most patients receive anti-TNF medication, but no long-term results of this expensive medication have been described, nor has its efficiency been compared to surgical strategies. With this study, we hope to provide treatment consensus for daily clinical practice with reduction in costs.