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dc.contributor.authorCrowley, R K
dc.contributor.authorAl-Derazi, Y
dc.contributor.authorLynch, K
dc.contributor.authorRawluk, D
dc.contributor.authorThompson, C J
dc.contributor.authorFarrell, M
dc.contributor.authorAgha, A
dc.date.accessioned2011-04-05T15:25:18Z
dc.date.available2011-04-05T15:25:18Z
dc.date.issued2009-09-30
dc.identifier.citationAcromegaly associated with gangliocytoma. 2009: Ir J Med Scien
dc.identifier.issn1863-4362
dc.identifier.pmid19789938
dc.identifier.doi10.1007/s11845-009-0433-2
dc.identifier.urihttp://hdl.handle.net/10147/127248
dc.description.abstractBACKGROUND: Acromegaly secondary to growth hormone-releasing hormone (GHRH) excess is rare. AIMS/CASE DESCRIPTION: We report two patients with acromegaly who were diagnosed with sellar gangliocytomas that were immunopositive for GHRH. Tumour tissue persisted after debulking surgery and in the second case this was associated with persistent growth hormone hypersecretion, successfully suppressed by a somatostatin analogue. CONCLUSIONS: The development of functional pituitary adenomas in association with sellar gangliocytomas is poorly understood. We present a brief discussion of the possible aetiology of these unusual pituitary tumours.
dc.languageENG
dc.titleAcromegaly associated with gangliocytoma.en
dc.typeArticle In Pressen
dc.contributor.departmentAcademic Department of Endocrinology, Beaumont Hospital, Dublin 9, Ireland, rachelcrowley@hotmail.com.en
dc.identifier.journalIrish journal of medical scienceen
dc.description.provinceLeinster
html.description.abstractBACKGROUND: Acromegaly secondary to growth hormone-releasing hormone (GHRH) excess is rare. AIMS/CASE DESCRIPTION: We report two patients with acromegaly who were diagnosed with sellar gangliocytomas that were immunopositive for GHRH. Tumour tissue persisted after debulking surgery and in the second case this was associated with persistent growth hormone hypersecretion, successfully suppressed by a somatostatin analogue. CONCLUSIONS: The development of functional pituitary adenomas in association with sellar gangliocytomas is poorly understood. We present a brief discussion of the possible aetiology of these unusual pituitary tumours.


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