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dc.contributor.authorMahajan, V A
dc.contributor.authorNi Chonghaile, M
dc.contributor.authorBokhari, S A
dc.contributor.authorHarte, B H
dc.contributor.authorFlynn, N M
dc.contributor.authorLaffey, J G
dc.date.accessioned2011-04-11T10:23:32Z
dc.date.available2011-04-11T10:23:32Z
dc.date.issued2007-06
dc.identifier.citationRecovery of older patients undergoing ambulatory anaesthesia with isoflurane or sevoflurane. 2007, 24 (6):505-10 Eur J Anaesthesiolen
dc.identifier.issn0265-0215
dc.identifier.pmid17202009
dc.identifier.doi10.1017/S0265021506001980
dc.identifier.urihttp://hdl.handle.net/10147/127917
dc.description.abstractDelayed recovery of cognitive function is a well-recognized phenomenon in older patients. The potential for the volatile anaesthetic used to contribute to alterations in postoperative cognitive function in older patients following minor surgical procedures has not been determined. We compared emergence from isoflurane and sevoflurane anaesthesia in older surgical patients undergoing urological procedures of short duration.
dc.description.abstractSeventy-one patients, 60 yr of age or older, undergoing anaesthesia expected to last less than 60 min for ambulatory surgery, were randomly assigned to receive isoflurane or sevoflurane. A standardized anaesthetic protocol was used, with intravenous fentanyl 1 microg kg(-1) and propofol 1.5-2.0 mg kg(-1) administered to induce anaesthesia. Anaesthesia was maintained with either sevoflurane or isoflurane in 65% nitrous oxide and oxygen. Early and intermediate recovery times were recorded. The Mini Mental State Examination and digit repetition forwards and backwards were administered at baseline, and at 1, 3 and 6 h postoperatively, to assess cognitive function.
dc.description.abstractThere were no between-group differences in (sevoflurane vs. isoflurane, mean +/- standard error of the mean) times to removal of the laryngeal mask airway (7.7 +/- 0.6 vs. 7.1 +/- 0.4 min), verbal response time (10.1 +/- 0.7 vs. 9.9 +/- 0.7 min) and orientation (12.1 +/- 0.7 vs. 12.1 +/- 0.7 min). Intermediate recovery, as measured by time to readiness for discharge from the post anaesthesia care unit (44.9 +/- 1.5 vs. 44.3 +/- 1.5 min), was similar in the two groups. Postoperative indices of cognitive function and attention were comparably reduced at 1 h, but returned to baseline in both groups at 6 h.
dc.description.abstractIsoflurane and sevoflurane anaesthesia resulted in similar clinical and neurocognitive recovery profiles in older patients undergoing ambulatory surgical procedures of short duration.
dc.language.isoenen
dc.subject.meshAged
dc.subject.meshAmbulatory Surgical Procedures
dc.subject.meshAnalysis of Variance
dc.subject.meshAnesthesia, Inhalation
dc.subject.meshAnesthetics, Inhalation
dc.subject.meshCognition Disorders
dc.subject.meshDouble-Blind Method
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshIsoflurane
dc.subject.meshMale
dc.subject.meshMethyl Ethers
dc.subject.meshNeuropsychological Tests
dc.subject.meshOrientation
dc.subject.meshProspective Studies
dc.subject.meshTime Factors
dc.subject.meshUrologic Surgical Procedures
dc.titleRecovery of older patients undergoing ambulatory anaesthesia with isoflurane or sevoflurane.en
dc.typeArticleen
dc.contributor.departmentNational University of Ireland, Clinical Sciences Institute, and National Centre for Biomedical Engineering Sciences (NCBES), Department of Anaesthesia, Galway, Ireland.en
dc.identifier.journalEuropean journal of anaesthesiologyen
dc.description.provinceConnacht
html.description.abstractDelayed recovery of cognitive function is a well-recognized phenomenon in older patients. The potential for the volatile anaesthetic used to contribute to alterations in postoperative cognitive function in older patients following minor surgical procedures has not been determined. We compared emergence from isoflurane and sevoflurane anaesthesia in older surgical patients undergoing urological procedures of short duration.
html.description.abstractSeventy-one patients, 60 yr of age or older, undergoing anaesthesia expected to last less than 60 min for ambulatory surgery, were randomly assigned to receive isoflurane or sevoflurane. A standardized anaesthetic protocol was used, with intravenous fentanyl 1 microg kg(-1) and propofol 1.5-2.0 mg kg(-1) administered to induce anaesthesia. Anaesthesia was maintained with either sevoflurane or isoflurane in 65% nitrous oxide and oxygen. Early and intermediate recovery times were recorded. The Mini Mental State Examination and digit repetition forwards and backwards were administered at baseline, and at 1, 3 and 6 h postoperatively, to assess cognitive function.
html.description.abstractThere were no between-group differences in (sevoflurane vs. isoflurane, mean +/- standard error of the mean) times to removal of the laryngeal mask airway (7.7 +/- 0.6 vs. 7.1 +/- 0.4 min), verbal response time (10.1 +/- 0.7 vs. 9.9 +/- 0.7 min) and orientation (12.1 +/- 0.7 vs. 12.1 +/- 0.7 min). Intermediate recovery, as measured by time to readiness for discharge from the post anaesthesia care unit (44.9 +/- 1.5 vs. 44.3 +/- 1.5 min), was similar in the two groups. Postoperative indices of cognitive function and attention were comparably reduced at 1 h, but returned to baseline in both groups at 6 h.
html.description.abstractIsoflurane and sevoflurane anaesthesia resulted in similar clinical and neurocognitive recovery profiles in older patients undergoing ambulatory surgical procedures of short duration.


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