• All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection.

      Mocanu, Edgar; Shattock, Richard; Barton, David; Rogers, Melissa; Conroy, Ronan; Sheils, Orla; Collins, Claire; Martin, Cara; Harrison, Robert; O'Leary, John; et al. (2012-02-01)
      We assessed the frequency of CFTR mutations in groups with varying degrees of sub-fertility and compared these groups to a fertile male group with proven paternity. Screening for CFTR mutations should be routine for all azoospermic males, irrespective of obstructive or non-obstructive etiology, prior to proposing ICSI treatment. CFTR testing has no value in the investigation of non-azoospermic infertile males.