• Silencing Dkk1 expression rescues dexamethasone-induced suppression of primary human osteoblast differentiation.

      Butler, Joseph S; Queally, Joseph M; Devitt, Brian M; Murray, David W; Doran, Peter P; O'Byrne, John M; Clinical Research Centre, UCD School of Medicine & Medical Science, Mater Misericordiae University Hospital, Dublin, Ireland. josephsbutler@hotmail.com (2010-09)
      The Wnt/β-catenin pathway is a major signaling cascade in bone biology, playing a key role in bone development and remodeling. The objectives of this study were firstly, to determine the effects of dexamethasone exposure on Wnt/β-catenin signaling at an intracellular and transcriptional level, and secondly, to assess the phenotypic effects of silencing the Wnt antagonist, Dickkopf-1 (Dkk1) in the setting of dexamethasone exposure.