• The association between TNF-α and insulin resistance in euglycemic women.

      Walsh, Jennifer M; McGowan, Ciara A; Byrne, Jacinta A; Rath, Ann; McAuliffe, Fionnuala M; UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, Ireland; National Maternity Hospital, Dublin, Ireland. Electronic address: msjenniferwalsh@gmail.com. (2013-10)
      Chronic low levels of inflammation have links to obesity, diabetes and insulin resistance. We sought to assess the relationship between cytokine tumor necrosis factor (TNF-α) and insulin resistance in a healthy, euglycemic population. This is a prospective study of 574 non-diabetic mother and infant pairs. Maternal body mass index (BMI), TNF-α, glucose and insulin were measured in early pregnancy and at 28 weeks. Insulin resistance was calculated by HOMA index. At delivery birthweight was recorded and cord blood analysed for fetal C-peptide and TNF-α. In a multivariate model, maternal TNF-α in early pregnancy was predicted by maternal insulin resistance at the same time-point, (β=0.54, p<0.01), and maternal TNF-α at 28 weeks was predicted by maternal insulin resistance in early pregnancy (β=0.24, p<0.01) and at 28 weeks (β=0.39, p<0.01). These results, in a large cohort of healthy, non-diabetic women have shown that insulin resistance, even at levels below those diagnostic of gestational diabetes, is associated with maternal and fetal inflammatory response. These findings have important implications for defining the pathways of fetal programming of later metabolic syndrome and childhood obesity.
    • Neonatal telephone consultations in the National Maternity Hospital

      Travers, CP; Murphy, JFA (Irish Medical Journal, 2014-09)
      Details of telephone consultations concerning infants were recorded prospectively over a two month period in the National Maternity Hospital (NMH). There were one hundred and forty-six calls recorded. One hundred and sixteen (79.5%) calls were from mothers. The average age of the infants was twenty-eight days. Eighty (54.8%) calls were answered by Nursing Staff while the remainder were taken by Doctors. There were thirty-nine (26.7%) calls relating to the gastrointestinal system. There were twenty-seven (18.5%) calls regarding infants with respiratory concerns. The next most common problem was irritability followed by calls concerning jaundice, rashes and umbilical issues. Fifty-five (37.7%) callers were given home care advice or reassurance. Thirty-six (24.7%) were advised to attend a Paediatric Emergency Department (ED). GP visits and Baby Clinic appointments were advised for twenty-four (16.4%) and twenty-three (15.8%) infants respectively while six (4.1%) of the callers were directed to attend NMH immediately.
    • Neurodevelopmental outcome of preterm babies of 1999-2009

      Huggard, D; Slevin, M; Vavasseur, C (Irish Medical Journal, 2014-06)
      The Bayley scale of infant development is employed as the performance indicator at 2 years corrected gestational age for high risk paediatric groups. We compare neurodevelopmental outcomes in two cohorts of VLBW infants born in 1999 to a cohort born a decade later, while also examining the challenges of direct comparison of modified scales: BSID-II (2nd edition of the scales) with Bayley III. BSID â II was used in the 1999 group and Bayley-III for the 2009 cohort. We demonstrated that over a ten year period there was an improvement in neurodevelopmental scores achieved in VLBW babies. Overall there was almost an 8 point increase in the cognitive scores from the 2009 cohort compared with the 1999 cohort in this time period. The mean motor score increased by 6 points when comparing 1999 and 2009. However we highlight the difficulties in comparing developmental scales, and consider whether Bayley-III overestimates developmental ability?
    • Planned hospital discharge: A strategy for reducing lenght of stay of low birth weight (VLBW<1500g) infants in NICU

      Neary, E; Al-Assaf, N; MCDermott, C; Sheehan, K; Kirkham, C; Corcoran, D; Molloy, E; McCallion, N; Clarke, T (Pediatric Research, 2011-11)
      52nd Annual Meeting of the European Society for Paediatric Research Newcastle UK October 2011
    • Plastics bags reduce hypothermia in newly born infants in the developing world.

      O'Donnell, Colm P F; Department of Neonatology, The National Maternity Hospital, , Dublin, Ireland. (2014-04)
    • Poor motor outcome at 2 years of age in predicted by elevated leukocyte count in infants with perinatal asphyxia

      Sweetman, DU; Lakatos, P; Molloy, EJ (Archive of Disease in Childhood, 2012-10)
    • The role of cephalocentesis in the management of the severely hydrocephalic fetus

      Howse, E; Teoh, T; Kelly, E; Chitayat, D; McParland, P; Ryan, G (Ultrasound in Obstetrics and Gynecology, 2011-10)
      21st World Congress on Ultrasound in Obstetrics and Gynecology