• Effect of injury on S1 dorsal root ganglia in an experimental model of neuropathic faecal incontinence.

      Peirce, C; O'Herlihy, C; O'Connell, P R; Jones, J F X; School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland. (The British journal of surgery, 2011-08)
      An experimental model of neuropathic faecal incontinence has recently been established. This study aimed to quantify and compare the effect of crush and compression injury on first-order sensory neurones of the inferior rectal nerve (IRN) using a nuclear marker of axonal injury, activating transcription factor (ATF) 3.
    • Sacral nerve stimulation increases activation of the primary somatosensory cortex by anal canal stimulation in an experimental model.

      Griffin, K M; Pickering, M; O'Herlihy, C; O'Connell, P R; Jones, J F X; Health Sciences Centre, School of Medicine and Medical Sciences, University College Dublin, Ireland. (The British journal of surgery, 2011-08)
      Sacral and posterior tibial nerve stimulation may be used to treat faecal incontinence; however, the mechanism of action is unknown. The aim of this study was to establish whether sensory activation of the cerebral cortex by anal canal stimulation was increased by peripheral neuromodulation.