• Antenatal suspicion of ischemic placental disease and coexistence of maternal and fetal placental disease: analysis of over 500 cases.

      Cooley, Sharon M; Reidy, Fiona R; Mooney, Eoghan E; McAuliffe, Fionnuala M; Fetal Medicine Center, National Maternity Hospital, Dublin, Ireland. (2011-12)
      To investigate the antenatal suspicion of placental disease and the coexistence of maternal and fetal placental ischemic disease.
    • The application of a clinical risk stratification score may reduce unnecessary investigations for pulmonary embolism in pregnancy.

      O'Connor, Clare; Moriarty, John; Walsh, Jennifer; Murray, John; Coulter-Smith, Sam; Boyd, William; Department of Obstetrics and Gynaecology, National Maternity Hospital, Dublin, Ireland. (2011-12)
      To examine the use of the modified Wells score in pregnancy as a risk stratification tool in the diagnosis of pulmonary embolism (PE).
    • Appropriate antenatal corticosteroid use in women at risk for preterm birth before 34 weeks of gestation.

      Mahony, R; McKeating, A; Murphy, T; McAuliffe, F; O'Herlihy, C; Foley, M; National Maternity Hospital Dublin, Holles Street, Dublin 2, Ireland. (2010-07)
      To determine the utilisation of antenatal corticosteroid administration in women presenting at risk of preterm birth (PTB) in a centre where tocolytics are not prescribed.
    • Dietary iodine intake in pregnancy: an update.

      Smyth, P; O'Herlihy, C (Irish Medical Journal (IMJ), 2012-01)
    • The dual influences of age and obstetric history on fecal continence in parous women.

      Eogan, Maeve; O'Brien, Conor; Daly, Leslie; Behan, Michael; O'Connell, P Ronan; O'Herlihy, Colm; Department of Obstetrics and Gynaecology, University College Dublin, National Maternity Hospital, Dublin, Ireland. (2011-02)
      To assess whether women who underwent forceps delivery were more likely than those who delivered either normally (spontaneous vaginal delivery [SVD]) or by cesarean to experience deterioration in fecal continence as they aged.
    • Fetal death in twins.

      Mahony, Rhona; Mulcahy, Celia; McAuliffe, Fionnuala; Herlihy, Colm O; Carroll, Stephen; Foley, Michael E; Department of Obstetrics and Gynaecology, National Maternity Hospital, University College Dublin, Dublin, Ireland. rhonamahony@hotmail.com (2011-11)
      To examine the pattern and prospective risk of intrauterine fetal death (IUFD) in twin pregnancy by chorionicity.
    • Interpregnancy weight changes and impact on pregnancy outcome in a cohort of women with a macrosomic first delivery: a prospective longitudinal study.

      Crosby, David A; Walsh, Jennifer M; Segurado, Ricardo; McAuliffe, Fionnuala M; Department of Obstetrics and Gynaecology, National Maternity Hospital, Dublin, Ireland. UCD Perinatal Research Centre, School of Medicine, University College Dublin, Dublin, Ireland. CSTAR, School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Ireland. (BMJ Publishing Group Ltd, 2017-06-06)
      To determine the median interpregnancy maternal weight change between first and second pregnancies, and second and third pregnancies and to assess the impact of this weight change on pregnancy outcome in a cohort of women with a macrosomic first delivery.
    • Low glycaemic index diet in pregnancy to prevent macrosomia (ROLO study): randomised control trial.

      Walsh, Jennifer M; McGowan, Ciara A; Mahony, Rhona; Foley, Michael E; McAuliffe, Fionnuala M; UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland. (2012-08)
      To determine if a low glycaemic index diet in pregnancy could reduce the incidence of macrosomia in an at risk group.
    • Obstetric outcome with low molecular weight heparin therapy during pregnancy.

      Donnelly, J; Byrne, J; Murphy, K; McAuliffe, F; Department of Obstetrics and Gynaecology, National Maternity Hospital, Holles St, Dublin 2. jenniferdonnelly@mac.com (Irish Medical Journal (IMJ), 2012-01)
      This was a prospective study of women attending a combined haematology/obstetric antenatal clinic in the National Maternity Hospital (2002-2008). Obstetric outcome in mothers treated with low molecular weight heparin (LMWH) was compared to the general obstetric population of 2006. There were 133 pregnancies in 105 women. 85 (63.9%) received prophylactic LMWH and 38 (28.6%) received therapeutic LMWH in pregnancy. 10 (7.5%) received postpartum prophylaxis only. The perinatal mortality rate was 7.6/1000 births. 14 (11.3%) women delivered preterm which is significantly higher than the hospital population rate (5.7%, p<0.05). Despite significantly higher labour induction rates (50% vs 29.2% p<0.01), there was no difference in CS rates compared to the general hospital population (15.4% vs 18.9%, NS). If carefully managed, these high-risk women can achieve similar vaginal delivery rates as the general obstetric population.
    • A randomised control trial of low glycaemic index carbohydrate diet versus no dietary intervention in the prevention of recurrence of macrosomia.

      Walsh, Jennifer; Mahony, Rhona; Foley, Michael; Mc Auliffe, Fionnuala; Department of Obstetrics and Gynaecology, University College Dublin National Maternity Hospital, Dublin, Ireland. jennifer.walsh@ucd.ie (2010)
      Maternal weight and maternal weight gain during pregnancy exert a significant influence on infant birth weight and the incidence of macrosomia. Fetal macrosomia is associated with an increase in both adverse obstetric and neonatal outcome, and also confers a future risk of childhood obesity. Studies have shown that a low glycaemic diet is associated with lower birth weights, however these studies have been small and not randomised 12. Fetal macrosomia recurs in a second pregnancy in one third of women, and maternal weight influences this recurrence risk 3.
    • The relationship between maternal and fetal vitamin D, insulin resistance, and fetal growth.

      Walsh, Jennifer M; McGowan, Ciara A; Kilbane, Mark; McKenna, Malachi J; McAuliffe, Fionnuala M; UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland (2013-05)
      Evidence for a role of vitamin D in maintaining normal glucose homeostasis is inconclusive. We sought to clarify the relationship between maternal and fetal insulin resistance and vitamin D status. This is a prospective cohort study of 60 caucasian pregnant women. Concentrations of 25-hydroxyvitamin D (25-OHD), glucose, insulin, and leptin were measured in early pregnancy and at 28 weeks. Ultrasound at 34 weeks assessed fetal anthropometry including abdominal wall width, a marker of fetal adiposity. At delivery birth weight was recorded and fetal 25-OHD, glucose, C-peptide, and leptin measured in cord blood. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA) equation. We found that those with lower 25-OHD in early pregnancy had higher HOMA indices at 28 weeks, (r = -.32, P = .02). No significant relationship existed between maternal or fetal leptin and 25-OHD, or between maternal or fetal 25-OHD and fetal anthropometry or birth weight. The incidence of vitamin D deficiency was high at each time point (15%-45%). These findings lend support to routine antenatal supplementation with vitamin D in at risk populations.
    • Villitis of unknown aetiology: correlation of recurrence with clinical outcome.

      Feeley, L; Mooney, E E; Department of Pathology and Laboratory Medicine, National Maternity Hospital, Dublin, Ireland. (2010)
      Villitis of unknown aetiology (VUA) is associated with adverse pregnancy outcome. Consequently, an ability to predict recurrence could be clinically relevant. We examined placentas where villitis was diagnosed in a previous pregnancy to establish the risk of recurrence and outcome. A total of 304 cases of VUA were diagnosed in our laboratory over a 4-year period. Subsequently, 19 of this cohort had a second placenta examined histologically. Recurrence and clinical outcome were recorded. Villitis recurred in 7 of 19 cases (37%). There was a high level of adverse pregnancy outcome in this cohort overall, characterised by small for gestational age infants and stillbirth, particularly in cases with high-grade villitis. We identified recurrent villitis more frequently than previously reported. Our findings confirm an association between high-grade villitis and poor outcome. Adequately powered prospective studies are required to determine if enhanced surveillance of subsequent pregnancies is indicated following a diagnosis of villitis.