• Identification of a myometrial molecular profile for dystocic labor.

      Brennan, Donal J; McGee, Sharon F; Rexhepaj, Elton; O'Connor, Darran P; Robson, Michael; O'Herlihy, Colm; National Maternity Hospital, Dublin , Ireland. (2011)
      The most common indication for cesarean section (CS) in nulliparous women is dystocia secondary to ineffective myometrial contractility. The aim of this study was to identify a molecular profile in myometrium associated with dystocic labor.
    • Identification of those most likely to benefit from a low-glycaemic index dietary intervention in pregnancy.

      Walsh, Jennifer M; Mahony, Rhona M; Canty, Gillian; Foley, Michael E; McAuliffe, Fionnuala M; UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital,Dublin,Republic of Ireland. (2014-08-28)
      The present study is a secondary analysis of the ROLO study, a randomised control trial of a low-glycaemic index (GI) diet in pregnancy to prevent the recurrence of fetal macrosomia. The objectives of the present study were to identify which women are most likely to respond to a low-GI dietary intervention in pregnancy with respect to three outcome measures: birth weight; maternal glucose intolerance; gestational weight gain (GWG). In early pregnancy, 372 women had their mid-upper arm circumference recorded and BMI calculated. Concentrations of glucose, insulin and leptin were measured in early pregnancy and at 28 weeks. At delivery, infant birth weight was recorded and fetal glucose, C-peptide and leptin concentrations were measured in the cord blood. Women who benefited in terms of infant birth weight were shorter, with a lower education level. Those who maintained weight gain within the GWG guidelines were less overweight in both their first and second pregnancies, with no difference being observed in maternal height. Women who at 28 weeks of gestation developed glucose intolerance, despite the low-GI diet, had a higher BMI and higher glucose concentrations in early pregnancy with more insulin resistance. They also had significantly higher-interval pregnancy weight gain. For each analysis, women who responded to the intervention had lower leptin concentrations in early pregnancy than those who did not. These findings suggest that the maternal metabolic environment in early pregnancy is important in determining later risks of excessive weight gain and metabolic disturbance, whereas birth weight is mediated more by genetic factors. It highlights key areas, which warrant further interrogation before future pregnancy intervention studies, in particular, maternal education level and inter-pregnancy weight gain.
    • Imaging and assessment of placental function.

      Moran, Mary; McAuliffe, Fionnuala M; School of Medicine and Medical Science, University College Dublin, Dublin, Ireland. (Journal of clinical ultrasound : JCU, 2011-09)
      The placenta is the vital support organ for the developing fetus. This article reviews current ultrasound (US) methods of assessing placental function. The ability of ultrasound to detect placental pathology is discussed. Doppler technology to investigate the fetal, placental, and maternal circulations in both high-risk and uncomplicated pregnancies is discussed and the current literature on the value of three-dimensional power Doppler studies to assess placental volume and vascularization is also evaluated. The article highlights the need for further research into three-dimensional ultrasound and alternative methods of placental evaluation if progress is to be made in optimizing placental function assessment.
    • The impact of diet, body composition, and physical activity on child bone mineral density at five years of age-findings from the ROLO Kids Study.

      McVey, Marco K; Geraghty, Aisling A; O'Brien, Eileen C; McKenna, Malachi J; Kilbane, Mark T; Crowley, Rachel K; Twomey, Patrick J; McAuliffe, Fionnuala M (2019-11-01)
      Bone health is extremely important in early childhood because children with low bone mineral density (BMD) are at a greater risk of bone fractures. While physical activity and intake of both calcium and vitamin D benefit BMD in older children, there is limited research on the determinants of good bone health in early childhood. The aim of this cross-sectional study was to investigate the impact of diet, physical activity, and body composition on BMD at five years of age. Dietary intakes and physical activity levels were measured through questionnaires. Whole body BMD was measured by dual-energy X-ray absorptiometry in 102 children. Child weight, height, circumferences, skinfolds and serum 25-hydroxyvitamin D (25OHD) concentrations were assessed. There was no association between BMD and dietary calcium, dietary vitamin D, 25OHD, physical activity, or sedentary behaviour. Several measures of body composition were significantly positively associated with BMD; however, neither fat mass nor lean body mass was associated with BMD.Conclusion: Although we found no association between self-reported dietary and lifestyle factors and bone health in early years, increased body size was linked with higher BMD. These findings are important as identifying modifiable factors that can improve bone health at a young age is of utmost importance.What is Known:• Bone health is extremely important in early childhood, as children with low bone mineral density (BMD) are at greater risk of bone fractures.• Physical activity has been found to be beneficial for bone health in adolescents, and body composition has also been associated with BMD in teenage years.• Limited research on the determinants of good bone health in early childhood.What is New:• No association between self-reported lifestyle and dietary factors with bone health in early childhood.• Increased body size was associated with higher BMD at five years of age.
    • Impact of maternal age and parity in management ansd outcome of major obstetric haemorrhage

      O'Connor, H; Hehir, M; Walsh, J; Fitzpatrick, C; Coulter-Smith, S; Geary, M; Higgins, S; Malone, F (American Journal of Obstetrics and Gynaecology, 2012-01)
    • Impact of maternal and fetal adiposity on maternal and fetal vitamin D

      Walsh, J; Kilbane, M; Mahony, R (American Journal of Obstetrics and Gynaecology, 2012-01)
    • Improving Assessment During Noninvasive Ventilation in the Delivery Room

      Lista, G.; Schmolzer, G. M.; O'Donnell, C. P. F. (NeoReviews, 2012-06)
    • In vitro effect of exothermic mattresses on temperature in the delivery room.

      McCarthy, Lisa K; Hensey, Conor C; O'Donnell, Colm P F (Resuscitation, 2012-10)
    • Increasing rates of operative vaginal delivery across two decades: accompanying outcomes and instrument preferences.

      Hehir, Mark P; Reidy, Fiona R; Wilkinson, Michael N; Mahony, Rhona; National Maternity Hospital, Holles St, Dublin, Ireland. Electronic address: markhehir23@gmail.com. (2013-11)
      To examine rates and outcomes of operative vaginal delivery over a 20-year study period and the changing preference for various instruments during this period.
    • Induction of labour: A growing trend

      Fitzpatrick, C; Robson, M; Coulter-Smith, S; Flood, K; Malone, F; Murray, A; Uterscheider, J; Breathnach, F (Am J Obstet Gynecol, 2011-01)
      Society for Maternal-Fetal Medicine. The Pregnancy Meeting Feb 2011
    • Inflammatory protein expression in adolescent and adult offspring of type 1 diabetic mice.

      Dowling, Daniel; Corrigan, Niamh; Downey, Paul; McAuliffe, Fionnuala M; UCD Obstetrics & Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland. (Birth defects research. Part B, Developmental and reproductive toxicology, 2012-10)
      To measure inflammatory markers in offspring of pregestational type 1 diabetic mothers.
    • The influence of maternal glycaemia and dietary glycaemic index on pregnancy outcome in healthy mothers.

      McGowan, Ciara A; McAuliffe, Fionnuala M; UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, National Maternity Hospital, University College Dublin, Holles Street, Dublin 2, Republic of Ireland. (2010-07)
      Infant birth weight has increased in Ireland in recent years along with levels of childhood overweight and obesity. The present article reviews the current literature on maternal glycaemia and the role of the dietary glycaemic index (GI) and its impact on pregnancy outcomes. It is known that maternal weight and weight gain significantly influence infant birth weight. Fetal macrosomia (birth weight >4000 g) is associated with an increased risk of perinatal trauma to both mother and infant. Furthermore, macrosomic infants have greater risk of being obese in childhood, adolescence and adulthood compared to normal-sized infants. There is evidence that there is a direct relationship between maternal blood glucose levels during pregnancy and fetal growth and size at birth, even when maternal blood glucose levels are within their normal range. Thus, maintaining blood glucose concentrations within normal parameters during pregnancy may reduce the incidence of fetal macrosomia. Maternal diet, and particularly its carbohydrate (CHO) type and content, influences maternal blood glucose concentrations. However, different CHO foods produce different glycaemic responses. The GI was conceived by Jenkins in 1981 as a method for assessing the glycaemic responses of different CHO. Data from clinical studies in healthy pregnant women have documented that consuming a low-GI diet during pregnancy reduces peaks in postprandial glucose levels and normalises infant birth weight. Pregnancy is a physiological condition where the GI may be of particular relevance as glucose is the primary fuel for fetal growth.
    • Influence of oxytocin acceleration of nulliparous labour on perinatal outcome

      Ryan, HR; Robson, M; O'Herlihy, C (American Journal of Obstetrics Gynecology, 2012-01)
    • The influence of parity on maternal and neonatal outcomes in shoulder dystocia

      Hehir, M; Walsh, J; Robson, M (American Journal of Obstetrics and Gynaecology, 2012-01)
    • Insufficient vitamin D intakes among pregnant women.

      McGowan, C A; Byrne, J; Walsh, J; McAuliffe, F M; UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland. cmcgowa@gmail.com (2011-09)
      Vitamin D has an important role in pregnancy in promoting fetal skeletal health. Maternal dietary intake is a key factor influencing both maternal and fetal status. There are limited data available on food groups contributing to vitamin D intake in pregnancy. The aim of this study was to determine dietary intakes of vitamin D throughout pregnancy in 64 women and to determine the main food groups contributing to vitamin D intake. Results showed that median dietary intakes of vitamin D ranged from 1.9-2.1 μg/d during pregnancy, and were 80% below the current recommendation. The principal food groups contributing to vitamin D intake were meat, egg and breakfast cereal groups. Oily fish, the best dietary source of vitamin D, was consumed by <25% of women. These data call for more education; they question the role of vitamin D supplementation and highlight the contribution of other food groups more frequently consumed, namely, breakfast cereals, meat and eggs.
    • Insulin like growth factor axis in type 1 diabetic pregnancy

      Higgins, M; Russell, N; Crossey, P; Nyhan, K; Brazil, D; McAuliffe, F (Irish Journal of Medical Science, 2011-02)
      Institute of Obstetricians & Gynaecologists, RCPI Four Provinces Meeting, Junior Obstetrics & Gynaecology Society Annual Scientific Meeting, Royal Academy of Medicine in Ireland Dublin Maternity Hospitals Reports Meeting, Nov 2011
    • Interpregnancy weight changes and impact on pregnancy outcome in a cohort of women with a macrosomic first delivery: a prospective longitudinal study.

      Crosby, David A; Walsh, Jennifer M; Segurado, Ricardo; McAuliffe, Fionnuala M; Department of Obstetrics and Gynaecology, National Maternity Hospital, Dublin, Ireland. UCD Perinatal Research Centre, School of Medicine, University College Dublin, Dublin, Ireland. CSTAR, School of Public Health, Physiotherapy and Population Science, University College Dublin, Dublin, Ireland. (BMJ Publishing Group Ltd, 2017-06-06)
      To determine the median interpregnancy maternal weight change between first and second pregnancies, and second and third pregnancies and to assess the impact of this weight change on pregnancy outcome in a cohort of women with a macrosomic first delivery.
    • Interventions and outcomes infetal hydrops - a ten year experience

      O'Sullivan, C; Walsh, J; Hudson, A; Mahony, R (Irish Journal of Medical Science, 2011-02)
      Institute of Obstetricians & Gynaecologists, RCPI Four Provinces Meeting, Junior Obstetrics & Gynaecology Society Annual Scientific Meeting, Royal Academy of Medicine in Ireland Dublin Maternity Hospitals Reports Meeting, Nov 2010
    • Intraoperative hypothermia during cytoreductive surgery for ovarian cancer and perioperative morbidity.

      Moslemi-Kebria, Mehdi; El-Nashar, Sherif A; Aletti, Giovanni D; Cliby, William A; From the Divisions of Gynecology Surgery, Mayo Clinic, Rochester, Minnesota; and the Department of Obstetrics and Gynecology, Gynecological Oncology Service, Cleveland Clinic, Cleveland, Ohio. (2012-03)
      : To evaluate intraoperative hypothermia as a predictor for morbidity after open abdominal surgery for ovarian cancer.