• Ultrasonically detectable cerebellar haemorrhage in preterm infants.

      McCarthy, Lisa Kenyon; Donoghue, V; Murphy, J F A; Department of Neonatology, The National Maternity Hospital, Dublin, Ireland. lmccarthy@nmh.ie (2011-07)
      To determine the frequency and pattern of cerebellar haemorrhage (CBH) on routine cranial ultrasound (cUS) imaging in infants of ≤32 weeks gestation, and to investigate how extremely preterm infants with CBH differ from those with severe intraventricular haemorrhage (IVH).
    • Unmarried Mothers Delivered in the National Maternity Hospital - 1987

      Richardson, Valerie; Winston, Nessa; Department of Social Administration and Social Work, University College, Dublin 4. (The National Maternity Hospital Holles St, 1989)
      This report is the second in a series presenting the results of the on-going work of the Social Work Research Unit in the National Maternity Hospital. The Social Work Research Unit was set up in December 1985 as a joint project between the National Maternity Hospital and the Department of Social Work in University College, Dublin.
    • Unmarried Mothers Delivered in the National Maternity Hospital 1986

      Richardson, Valerie; Keenan, Jacqueline; Department of Social Administration & Social Work, University College, Dublin 4 (The National Maternity Office Holles St, 1987)
    • Unmarried Mothers Delivered in the National Maternity Hospital 1988

      Donohoe, Josephine; Fitzpatrick, Ann; Flanagan, Niamh; Scanlan, Sheila (National Maternity Hospital, Holles Street,, 1990)
    • Uptake of the Influenza Vaccination in Pregnancy

      Crosby, DA; Deleau, D; Brophy, C; Mcauliffe, FM; Mahony, R (Irish Medical Journal, 2016-09)
      Influenza is caused by a highly infectious RNA virus, which usually occurs in a seasonal pattern with epidemics in the winter months. The objective of this study was to determine the uptake of the influenza vaccine in a pregnant population and ascertain the reasons why some women did not receive it. A prospective cohort study was conducted over a two-week period in January 2016 in the National Maternity Hospital Dublin, a tertiary referral maternity hospital delivering over 9000 infants per year. There were 504 women studied over the 2-week period. Overall, 197(39.1%) women received the vaccine at a mean gestational age 20.9 weeks (SD 7.0). Given the increased rates of influenza in the community and the associated implications for mother and infant, it is important that pregnant women are educated regarding the risks of influenza in pregnancy and encourage this cohort to be vaccinated.
    • Use of Oxytocin in multiparous women in labour

      Chummum, K; Walsh, J; Shackleton, A; Boylan, P (Irish Journal of Medical Science, 2011)
      Institute of Obstetricians & Gynaecologists, RCPI Four Provinces Meeting Junior Obstetrics & Gynecology Society Annual Scientific Meeting, Royal Academy of Medicine in Ireland Dublin Matenity Hospitals Report Meeting Friday 26th Nov 2010
    • Villitis of unknown aetiology: correlation of recurrence with clinical outcome.

      Feeley, L; Mooney, E E; Department of Pathology and Laboratory Medicine, National Maternity Hospital, Dublin, Ireland. (2010)
      Villitis of unknown aetiology (VUA) is associated with adverse pregnancy outcome. Consequently, an ability to predict recurrence could be clinically relevant. We examined placentas where villitis was diagnosed in a previous pregnancy to establish the risk of recurrence and outcome. A total of 304 cases of VUA were diagnosed in our laboratory over a 4-year period. Subsequently, 19 of this cohort had a second placenta examined histologically. Recurrence and clinical outcome were recorded. Villitis recurred in 7 of 19 cases (37%). There was a high level of adverse pregnancy outcome in this cohort overall, characterised by small for gestational age infants and stillbirth, particularly in cases with high-grade villitis. We identified recurrent villitis more frequently than previously reported. Our findings confirm an association between high-grade villitis and poor outcome. Adequately powered prospective studies are required to determine if enhanced surveillance of subsequent pregnancies is indicated following a diagnosis of villitis.
    • Viral screening of couples undergoing partner donation in assisted reproduction with regard to EU Directives 2004/23/EC, 2006/17/EC and 2006/86/EC: what is the evidence for repeated screening?

      Wingfield, M; Cottell, E; Merrion Fertility Clinic, National Maternity Hospital, Dublin, Ireland. mwingfield@nmh.ie (2010-12)
      This paper concerns the requirements of the EU Tissue and Cells Directives with regard to the biological screening of donors of reproductive cells which are to be used for partner donation.
    • Vitamin D and neonatal immune function.

      Clancy, N; Onwuneme, C; Carroll, A; McCarthy, R; McKenna, M J; Murphy, N; Molloy, E J (2013-05)
      Vitamin D deficiency is widespread in the neonatal and paediatric population of northern latitudes, particularly in children of African, Middle Eastern and Asian ethnicity. This is associated with diminished immune function and increases the risk of Th1 autoimmune diseases like type 1 diabetes. Epidermiological studies have also shown a link between vitamin D deficiency in children and a more severe course of illness with lower respiratory tract infection or Respiratory Syncitial Virus (RSV) bronchiolitis. The mechanism by which vitamin D enhances immunity is complex. It acts through the innate immune system by inducing antimicrobial peptides in epithelial cells, neutrophils and macrophages. The role of Vitamin D in neonatal and paediatric immunomodulation requires further study.
    • Vitamin D deficiency is associated with altered hematologic indexes in very low birth weight infants.

      Velagapudi, Amit; McCarthy, Roberta; McKenna, Malachi; Brady, Jennifer; Murray, Barbara; Molloy, Eleanor J (The Journal of pediatrics, 2011-04)
    • Vitamin D Levels and myocardial function in preterm infants

      Armstrong, K; Onwunmeme, C; Franklin, O; Molloy, E (Archives of Disease in Childhood, 2013-08-20)
      Bakground Low Vitamin D levels have been linked to cardiac failure in the adults and children. Tissue Doppler Imaging (TDI) is evolving as a superior measure of subtle changes in myocardial contractility in preterm infants. We aimed to correlate Vitamin D levels at birth with TDI measures of systolic and diastolic function. Methods Preterm infants < 32 weeks gestation were recruited. Vitamin D levels were measured at birth and echocardiography was carried out on Day 1. TDI myocardial velocities were recorded using a pulsed wave doppler sample from the lateral left/right ventricular wall & intraventricular septum. Peak systolic (S’), early diastolic (E’) and late diastolic (A’) velocities were recorded. Results Ten preterm infants with structurally normal hearts were recruited. Mean (SD) gestational age was 28 (1.7) weeks and birthweight 1.29 (0.3)kg. There was no significant increase in Right ventricular systolic (5.1cm/sec vs 4.8cm/sec)or diastolic myocardial velocity measures (5.2cm/sec vs 5.1cm/sec) or left myocardial velocity systolic (3.7cm/sec vs 3.9cm/sec) or diastolic (4.1cm/sec vs 4.0cm/sec) measures between those with severe Vitamin D deficiency (<30 nmol/L) and those with low normal levels of Vitamin D. Conclusion Neonates with severe Vitamin D deficiency have similar TDI measures of systolic and diastolic velocity to those with near normal levels. In our small cohort severe Vitamin D deficiency appears to cause no impairment in myocardial contractility.
    • Vitamin D nutrient intake for all life stages.

      McKenna, M; McCarthy, R; Kilbane, M; Molloy, E (Irish medical journal, 2011-04)
      Vitamin D, unlike other nutrients, is a conditionally required nutrient being obtained from two sources – predominantly by skin production upon exposure to natural ultraviolet (UV) solar radiation, and to a lesser extent by oral intake. Being a fat soluble vitamin it has a long half-life of about two weeks and is stored in fat tissues.1 For nearly six months of the year from October to March in Ireland, skin production is absent and the population is dependent on oral intake from natural foodstuffs, (which are consumed in small quantities only), fortified foodstuffs (most notably some milk products for the past 25 years) and vitamin D supplements, either in multivitamin tablets or in combination with calcium tablets.
    • Vitamin D nutritional status in preterm infants and response to supplementation.

      McCarthy, Roberta A; McKenna, Malachi J; Oyefeso, Oyinkansola; Uduma, Ogenna; Murray, Barbara F; Brady, Jennifer J; Kilbane, Mark T; Murphy, John F; Twomey, Anne; O' Donnell, Colm P; et al. (2013-07-14)
      Little is known about vitamin D status in preterm infants and their response to supplementation. To investigate this, we assessed serum 25-hydroxyvitamin D (25OHD) levels using RIA in a consecutive sample of stable preterm very low birth weight (VLBW) infants (born ≤ 32 weeks gestation or birth weight ≤ 1·5 kg), and we explored associated factors. Serum 25OHD level was first assessed once infants were tolerating feeds (n 274). If this first 25OHD level was below 50 nmol/l (20 ng/ml), which is the level associated with covering requirements in terms of skeletal health in the majority, then we recommended prolonged augmented vitamin D intake ( ≥ 10 μg (400 IU) daily) from a combination of fortified feeds and vitamin supplements and follow-up re-assessment at approximately 6 weeks corrected age (n 148). The first assessment, conducted at a median for chronological age of 18 (interquartile range (IQR) 11-28) d, found that 78 % had serum 25OHD levels below 50 nmol/l. Multivariable analysis demonstrated that the determinants of serum 25OHD levels were duration of vitamin D supplementation and gestational age at birth (r 2 0·215; P< 0·001). At follow-up, after a median of 104 (IQR 78-127) d, 87 % achieved levels ≥ 50 nmol/l and 8 % had levels >125 nmol/l, a level associated with potential risk of harm. We conclude that low 25OHD levels are an issue for preterm VLBW infants, warranting early nutritional intervention. In infants with serum 25OHD levels < 50 nmol/l, a vitamin D intake of ≥ 10 μg (400 IU) daily achieves target levels in the majority; however, further work is needed to determine the exact dose to safely meet target levels without overcorrection.
    • Warming preterm infants in the delivery room: polyethylene bags, exothermic mattresses or both?

      McCarthy, Lisa K; O'Donnell, Colm P F; The National Maternity Hospital, Dublin 2, Ireland. lisamac79@yahoo.com (2011-12)
      To compare the admission temperature of infants treated with polyethylene bags alone to infants treated with exothermic mattresses in addition to bags in the delivery room.
    • Wasted - the years waiting for an alcohol policy

      Murphy, JFA (Irish Medical Journal, 2012-12)
      Throughout his lecture Bedford portrayed the close and complex relationship between Irish society and alcohol. Alcohol is part of our image both nationally and internationally. Some of the most abiding images of US presidential visits to Ireland are of drinking pints in Irish pubs. There is Arthur’s day and jump into Ireland. Alcohol is intertwined with our great sporting occasions and achievements. The famous Ireland vs England rugby match at Croke Park was set against the backdrop of intensive Guinness advertising. All Ireland final day has a strong association with the drinks industry.
    • What have shorter working hours for doctors achieved

      Murphy, J F A (Irish Medical Journal, 2011-04)
      The first years after qualification are difficult for all doctors. Itâ s a lot of responsibility for someone in their mid- twenties. The work is hard and complex and it takes time to acquire the ability to translate the theoretical knowledge acquired at medical school into clinical practice. Neal Chatterjee 1 has recently described the initial rawness and impact of hospital life on the new resident. There are ever-lit hallways, the cacophony of overhead pages, near constant bleeps and buzzes and the stale smell of hospital linen. Itâ s a foreign world in which the new doctor encounters daily stressful experiences. The question now being asked is whether it needs to be so daunting. Can the working conditions and the environment be improved?
    • What is the role and value of extra-mural medical activity

      Murphy, JFA (Irish Medical Journal, 2013-08-20)
      Presently all Irish doctors, apart from trainees, are in the process of getting their educational activities for the past year in order for enrolment in the new medical competence scheme. The intra-mural component is understandable and makes common sense. It gives an existence to oneâ s daily professional life. It is about meeting with oneâ s colleagues at least once a week to discuss aspects of patient care, review of radiological findings and the presentation of data from recent medical papers. The process is cost neutral, time efficient and beneficial for both patients and doctors. It is an important driver for the audit programme. In addition to its educational value it is good for team building and personal professional development. It may not sound very glamorous but its potential is considerable
    • What we can learn from generational gaps

      Higgins, MF; O'Gorman, C (Irish Medical Journal (IMJ), 2014-02)
      No matter what stage you are in your career, we defy you to deny that you have not had at least one of these thoughts recently - Medical students these days just don't have the respect for their seniors that we had. We need to learn! But when will we get the time! Social media has no place in medical education. Why can't I use my laptop in the hospital? As we moved slowly up the medical career ladder, we have gradually noticed the differences between the generations. These personal observations have been backed by a recent explosion in opinion articles, lectures and research in this area, much of which can help explain the issues and identify the background to the differences in opinion that previously may have frustrated or challenged relationships 1-3