• Should patients with extrapulmonary small-cell carcinoma receive prophylactic cranial irradiation?

      Naidoo, Jarushka; Teo, Min Yuen; Deady, Sandra; Comber, Harry; Calvert, Paula; * Department of Medical Oncology, Waterford Regional Hospital, Waterford, Ireland; †Department of Medical Oncology, The Adelaide and Meath Hospital Tallaght, Dublin, Ireland; and ‡Department of Research and Data Analysis, National Cancer Registry of Ireland, Cork, Ireland. (2013-09)
      Extrapulmonary small-cell carcinoma (EPSCC) is a rare disease. Management is based on small-cell lung carcinoma. Prophylactic cranial irradiation (PCI) is not routinely administered in EPSCC. This study investigates the role of PCI in EPSCC, by analyzing the incidence, treatment, and survival of patients with brain metastases in a national cohort. Disease biology and epidemiology are also investigated.