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dc.contributor.authorIsmail, Siti Khadijah
dc.contributor.authorHiggins, John R
dc.date.accessioned2011-07-01T11:25:10Z
dc.date.available2011-07-01T11:25:10Z
dc.date.issued2011-03
dc.identifier.citationHemostasis in pre-eclampsia. 2011, 37 (2):111-7 Semin. Thromb. Hemost.en
dc.identifier.issn1098-9064
dc.identifier.pmid21370210
dc.identifier.doi10.1055/s-0030-1270336
dc.identifier.urihttp://hdl.handle.net/10147/135091
dc.description.abstractPre-eclampsia (P-EC) is a multisystem disorder exclusive to pregnancy. It complicates ~2 to 8% of all pregnancies and remains a major cause of maternal mortality. P-EC is characterized by a profound hypercoagulable state. The delicate hemostatic balance that must be maintained in the uteroplacental circulation during pregnancy makes this system vulnerable to perturbation. An abnormal hemostatic pattern occurs within the uteroplacental circulation in P-EC compared with normal pregnancy. Much recent research has focused on the epidemiological link between inherited thrombophilia and P-EC. The data suggest a weak statistical association, indicating an improbable primary role in the pathogenesis. Without clear evidence, low molecular weight heparins have been widely used to reduce recurrence of P-EC in thrombophilia-positive women. This practice now should be reviewed. Future research needs to focus on improving our basic scientific understanding of the role of the hemostatic system in human placentation.
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/21370210en
dc.subject.meshAspirin
dc.subject.meshFemale
dc.subject.meshHemostasis
dc.subject.meshHeparin, Low-Molecular-Weight
dc.subject.meshHumans
dc.subject.meshHypertension, Pregnancy-Induced
dc.subject.meshPlacental Circulation
dc.subject.meshPlacentation
dc.subject.meshPre-Eclampsia
dc.subject.meshPregnancy
dc.subject.meshThrombophilia
dc.titleHemostasis in pre-eclampsia.en
dc.typeArticleen
dc.contributor.departmentAnu Research Centre, Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Ireland. k.ismail@ucc.ieen
dc.identifier.journalSeminars in thrombosis and hemostasisen
dc.description.provinceMunster
html.description.abstractPre-eclampsia (P-EC) is a multisystem disorder exclusive to pregnancy. It complicates ~2 to 8% of all pregnancies and remains a major cause of maternal mortality. P-EC is characterized by a profound hypercoagulable state. The delicate hemostatic balance that must be maintained in the uteroplacental circulation during pregnancy makes this system vulnerable to perturbation. An abnormal hemostatic pattern occurs within the uteroplacental circulation in P-EC compared with normal pregnancy. Much recent research has focused on the epidemiological link between inherited thrombophilia and P-EC. The data suggest a weak statistical association, indicating an improbable primary role in the pathogenesis. Without clear evidence, low molecular weight heparins have been widely used to reduce recurrence of P-EC in thrombophilia-positive women. This practice now should be reviewed. Future research needs to focus on improving our basic scientific understanding of the role of the hemostatic system in human placentation.


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