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    Secondary recurrent miscarriage is associated with previous male birth.

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    Authors
    Ooi, Poh Veh
    Russell, Noirin
    O'Donoghue, Keelin
    Affiliation
    Anu Research Centre, Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland.
    Issue Date
    2011-01
    MeSH
    Abortion, Habitual
    Cohort Studies
    Female
    HLA Antigens
    Humans
    Live Birth
    Male
    Parturition
    Pregnancy
    Pregnancy Complications
    Pregnancy Outcome
    Reproductive History
    Retrospective Studies
    Risk Factors
    Sex Factors
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    Citation
    Secondary recurrent miscarriage is associated with previous male birth. 2011, 88 (1):38-41 J. Reprod. Immunol.
    Journal
    Journal of reproductive immunology
    URI
    http://hdl.handle.net/10147/135765
    DOI
    10.1016/j.jri.2010.10.004
    PubMed ID
    21129780
    Abstract
    Secondary recurrent miscarriage (RM) is defined as three or more consecutive pregnancy losses after delivery of a viable infant. Previous reports suggest that a firstborn male child is associated with less favourable subsequent reproductive potential, possibly due to maternal immunisation against male-specific minor histocompatibility antigens. In a retrospective cohort study of 85 cases of secondary RM we aimed to determine if secondary RM was associated with (i) gender of previous child, maternal age, or duration of miscarriage history, and (ii) increased risk of pregnancy complications. Fifty-three women (62.0%; 53/85) gave birth to a male child prior to RM compared to 32 (38.0%; 32/85) who gave birth to a female child (p=0.002). The majority (91.7%; 78/85) had uncomplicated, term deliveries and normal birth weight neonates, with one quarter of the women previously delivered by Caesarean section. All had routine RM investigations and 19.0% (16/85) had an abnormal result. Fifty-seven women conceived again and 33.3% (19/57) miscarried, but there was no significant difference in failure rates between those with a previous male or female child (13/32 vs. 6/25, p=0.2). When patients with abnormal results were excluded, or when women with only one previous child were considered, there was still no difference in these rates. A previous male birth may be associated with an increased risk of secondary RM but numbers preclude concluding whether this increases recurrence risk. The suggested association with previous male birth provides a basis for further investigations at a molecular level.
    Item Type
    Article
    Language
    en
    ISSN
    1872-7603
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jri.2010.10.004
    Scopus Count
    Collections
    Cork University Maternity Hospital

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