• Cervical screening in cases of cervical cancer in Ireland between 2008 - 2018: RCOG Independent Expert Panel Review

      Royal College of Obstetricians and Gynaecologists (RCOG) (Royal College of Obstetricians and Gynaecologists (RCOG), 2019-11)
    • National Screening Service key performance indicator metadata 2019

      National Screening Service; Health Service Executive (HSE) (Health Service Executive (HSE), 2019-09)
    • International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis.

      Scott, Alasdair J; Alexander, James L; Merrifield, Claire A; Cunningham, David; Jobin, Christian; Brown, Robert; Alverdy, John; O'Keefe, Stephen J; Gaskins, H Rex; Teare, Julian; et al. (2019-05-15)
    • Circulating microRNAs miR-331 and miR-195 differentiate local luminal a from metastatic breast cancer.

      McAnena, Peter; Tanriverdi, Kahraman; Curran, Catherine; Gilligan, K; Freedman, Jane E; Brown, James A L; Kerin, Michael J (2019-05-10)
    • Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer.

      Kennedy, Sean P; Han, Jeremy Z R; Portman, Neil; Nobis, Max; Hastings, Jordan F; Murphy, Kendelle J; Latham, Sharissa L; Cadell, Antonia L; Miladinovic, Dushan; Marriott, Gabriella R; et al. (2019-03-21)
    • Design-functionality relationships for adhesion/growth-regulatory galectins.

      Ludwig, Anna-Kristin; Michalak, Malwina; Xiao, Qi; Gilles, Ulrich; Medrano, Francisco J; Ma, Hanyue; FitzGerald, Forrest G; Hasley, William D; Melendez-Davila, Adriel; Liu, Matthew; et al. (2019-02-04)
      Glycan-lectin recognition is assumed to elicit its broad range of (patho)physiological functions via a combination of specific contact formation with generation of complexes of distinct signal-triggering topology on biomembranes. Faced with the challenge to understand why evolution has led to three particular modes of modular architecture for adhesion/growth-regulatory galectins in vertebrates, here we introduce protein engineering to enable design switches. The impact of changes is measured in assays on cell growth and on bridging fully synthetic nanovesicles (glycodendrimersomes) with a chemically programmable surface. Using the example of homodimeric galectin-1 and monomeric galectin-3, the mutual design conversion caused qualitative differences, i.e., from bridging effector to antagonist/from antagonist to growth inhibitor and vice versa. In addition to attaining proof-of-principle evidence for the hypothesis that chimera-type galectin-3 design makes functional antagonism possible, we underscore the value of versatile surface programming with a derivative of the pan-galectin ligand lactose. Aggregation assays with N,N'-diacetyllactosamine establishing a parasite-like surface signature revealed marked selectivity among the family of galectins and bridging potency of homodimers. These findings provide fundamental insights into design-functionality relationships of galectins. Moreover, our strategy generates the tools to identify biofunctional lattice formation on biomembranes and galectin-reagents with therapeutic potential.
    • National Prostate Cancer GP Referral Guideline

      National Cancer Control Programme (Health Service Executive, 2018-10)
    • Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options

      McAnena, Peter F; Brown, James A; Ramli, A.; Curran, C.; Malone, C.; McLaughlin, R.; Barry, K.; JAL, Brown; Kerin, M. J (2018-02-20)
      Abstract Background Recent studies have shown that breast cancer subtype can change from the primary tumour to the recurrence. Discordance between primary and recurrent breast cancer has implications for further treatment and ultimately prognosis. The aim of the study was to determine the rate of change between primary and recurrence of breast cancer and to assess the impact of these changes on survival and potential treatment options. Methods Patient demographics were collected on those who underwent surgery for breast cancer between 2001 and 2014 and had a recurrence with biopsy results and pathology scoring of both the primary and recurrence. Results One hundred thirty two consecutive patients were included. There were 31 (23.5%) changes in subtype. Discordance occurred most frequently in luminal A breast cancer (n = 20), followed by triple negative (n = 4), luminal B (n = 3) and HER2 (n = 3). Patients who changed from luminal A to triple negative (n = 18) had a significantly worse post-recurrence survival (p < 0.05) with overall survival approaching significance (p = 0.064) compared to concordant luminal A cases (n = 46). Overall receptor discordance rates were: estrogen receptor 20.4% (n = 27), progesterone receptor 37.7% (n = 50) and HER2 3% (n = 4). Loss of estrogen receptor and progesterone receptor was more common than gain (21 vs. 6 (p = 0.04) and 44 vs. 6 (p = 0.01) respectively). Nine patients (6.8%) gained receptor status potentially impacting treatment options. Conclusion Discordance in subtype and receptor status occurs between primary and recurrent breast cancer, ultimately affecting survival and potentially impacting treatment options.
    • Sexual wellbeing after breast or pelvic cancer treatment: a guide for women

      National Cancer Control Programme (NCCP); Health Service Executive (Health Service Executive (HSE), 2018-01)
    • Diagnosis, staging and treatment of patients with lung cancer National Clinical Guideline No. 16

      National Cancer Control Programme (NCCP) (Department of Health, 2017-11)
    • BreastCheck: Programme Report 2015 - 2016

      BreastCheck, the National Breast Screening Programme (BreastCheck, the National Breast Screening Programme, 2017-08)
    • Information for men on sexual wellbeing after pelvic cancer treatment: what you should know

      National Cancer Control Programme (NCCP); Health Service Executive (Health Service Executive (HSE), 2016-11)
    • BreastCheck A decade of screening prior to age-extension

      Mooney, Therese; O’Neill, Sinead; McNally, Sara; Fitzpatrick, Patricia (2015)
    • Post treatment HPV testing as part of CervicalCheck, The National Cervical Screening programme in Ireland

      Flannelly, Grainne; Waldron, Maeve; Mooney, Therese; O‘Neill, Sinead; Fitzpatrick, Patricia (2015)
    • Long-term follow-up of women with breast cancer: rationale for policy change.

      McCarthy, T; Mullen, L; Murphy, H; Carey, D; Laffoy, M; National Cancer Control Programme, Kings Inns House, 200 Parnell St, Dublin, 1, Ireland, triona.mccarthy@cancercontrol.ie. (Springer, 2014-10-01)
      The number of breast cancer survivors in our ageing population continues to rise. Policy makers internationally are seeking to identify alternatives to follow-up care in an acute setting.
    • Development of National Electronic Cancer Referral in Ireland: a solution for a safer referral patient pathway [Poster]

      Nolan, E; Codd, R; Laffoy, M; Doogue, O; O’Mahony,B; Jordan, V; 1. National Cancer Control Programme (NCCP) 2. The National Healthlink Project 3. The National General Practice Information Technology (GPIT) Group 4. HSE ICT Directorate 5. The Irish College of General Practitioners (ICGP) (National Cancer Control Programme (NCCP), 2014-09)
    • Delivering care to oncology patients in the community: an innovative integrated approach.

      Hanan, Terry; Mullen, Louise; Laffoy, Marie; O'Toole, Eve; Richmond, Janice; Wynne, Mary (British Journal of Community Nursing, 2014-08)
      A community oncology nursing programme was developed in Ireland between the hospital and community health services for patients receiving systemic cancer therapy, in response to a service need. A robust evaluation of the pilot programme was undertaken, which found that defined clinical procedures traditionally undertaken in hospitals were safely undertaken in the patient's home with no adverse effects. There was a dramatic decrease in hospital attendances for these defined clinical procedures, and hospital capacity was consequently freed up. Patients valued having aspects of their care delivered at home and reported that it improved their quality of life, including reduced hospital visits and travel time. Community nurses expanded their scope of practice and became partners with oncology day-ward nurses in caring for these patients. Community nurses developed the competence and confidence to safely deliver cancer care in the community. This initiative shows that defined elements of acute cancer care can be safely delivered in the community so long as the training and support are provided. The findings and recommendations of the evaluation resulted in university accreditation and approval for national roll-out of the programme. Integration of services between primary and secondary care is a key priority. This innovative programme is a good example of shared integrated care that benefits both patients and health-care providers.
    • Age Related Influence on Screening Coverage and Satisfaction with CervicalCheck

      Fitzpatrick, P; O’Neill, S; Mooney, T; Duignan, A; Flannelly, G (Irish Medical Journal, 2014-07)
    • National Cancer Control Programme oncology medication safety review report

      National Cancer Control Programme (NCCP) (National Cancer Control Programme (NCCP), 2014-02)