• Age Related Influence on Screening Coverage and Satisfaction with CervicalCheck

      Fitzpatrick, P; O’Neill, S; Mooney, T; Duignan, A; Flannelly, G (Irish Medical Journal, 2014-07)
    • Assessing the real-world cost-effectiveness of adjuvant trastuzumab in HER-2/neu positive breast cancer.

      Hedden, Lindsay; O'Reilly, Susan; Lohrisch, Caroline; Chia, Stephen; Speers, Caroline; Kovacic, Laurel; Taylor, Suzanne; Peacock, Stuart; Canadian Centre for Applied Research in Cancer Control, Vancouver, BC, V5Z 1L3 Canada. (2012)
      Among women with surgically removed, high-risk HER-2/neu-positive breast cancer, trastuzumab has demonstrated significant improvements in disease-free and overall survival. The objective of this study is to evaluate the cost-effectiveness of the currently recommended 12-month adjuvant protocol of trastuzumab using a Markov modeling approach and real-world cost data.
    • Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options

      McAnena, Peter F; Brown, James A; Ramli, A.; Curran, C.; Malone, C.; McLaughlin, R.; Barry, K.; JAL, Brown; Kerin, M. J (2018-02-20)
      Abstract Background Recent studies have shown that breast cancer subtype can change from the primary tumour to the recurrence. Discordance between primary and recurrent breast cancer has implications for further treatment and ultimately prognosis. The aim of the study was to determine the rate of change between primary and recurrence of breast cancer and to assess the impact of these changes on survival and potential treatment options. Methods Patient demographics were collected on those who underwent surgery for breast cancer between 2001 and 2014 and had a recurrence with biopsy results and pathology scoring of both the primary and recurrence. Results One hundred thirty two consecutive patients were included. There were 31 (23.5%) changes in subtype. Discordance occurred most frequently in luminal A breast cancer (n = 20), followed by triple negative (n = 4), luminal B (n = 3) and HER2 (n = 3). Patients who changed from luminal A to triple negative (n = 18) had a significantly worse post-recurrence survival (p < 0.05) with overall survival approaching significance (p = 0.064) compared to concordant luminal A cases (n = 46). Overall receptor discordance rates were: estrogen receptor 20.4% (n = 27), progesterone receptor 37.7% (n = 50) and HER2 3% (n = 4). Loss of estrogen receptor and progesterone receptor was more common than gain (21 vs. 6 (p = 0.04) and 44 vs. 6 (p = 0.01) respectively). Nine patients (6.8%) gained receptor status potentially impacting treatment options. Conclusion Discordance in subtype and receptor status occurs between primary and recurrent breast cancer, ultimately affecting survival and potentially impacting treatment options.
    • BreastCheck A decade of screening prior to age-extension

      Mooney, Therese; O’Neill, Sinead; McNally, Sara; Fitzpatrick, Patricia (2015)
    • BreastCheck annual report 2004/2005

      BreastCheck, the National Breast Screening Programme (BreastCheck, the National Breast Screening Programme, 2005-11)
    • BreastCheck programme report 2007/2008

      BreastCheck; National Cancer Screening Service (NCSS) (BreastCheck, 2009)
    • Breastcheck programme report 2010-2011

      National Cancer Screening Service (NCSS) (National Cancer Screening Service (NCSS), 2012-01)
    • BreastCheck, the National Breast Screening Programme annual report 2005/2006

      BreastCheck, the National Breast Screening Programme (BreastCheck, the National Breast Screening Programme, 2006)
    • BreastCheck: Programme Report 2015 - 2016

      BreastCheck, the National Breast Screening Programme (BreastCheck, the National Breast Screening Programme, 2017-08)
    • Cancer incidence and mortality due to alcohol: An analysis of 10-year data

      Laffoy, M; Mc Carthy, T; Mullen, L; Byrne, D; Martin, J (Irish Medical Journal (IMJ), 2013-12)
    • Cervical check programme report 1 September 2010 – 31 August 2011

      National Cervical Screening Programme (National Cervical Screening Programme, 2012-10)
    • Cervical screening in cases of cervical cancer in Ireland between 2008 - 2018: RCOG Independent Expert Panel Review

      Royal College of Obstetricians and Gynaecologists (RCOG) (Royal College of Obstetricians and Gynaecologists (RCOG), 2019-11)
    • CervicalCheck programme report 2008-2009

      National Cancer Screening Service (NCSS); Health Service Executive (HSE) (National Cancer Screening Service (NCSS), 2010)
    • CervicalCheck programme report 2009-2010

      National Cancer Screening Service (NCSS); Health Service Executive (HSE) (Health Service Executive (HSE), 2011-09-22)
    • CervicalCheck: The first five years

      Flannelly, Grainne; Mooney, Therese; O’Neill, Sinead; McNally, Sara; Fitzpatrick, Patricia (2015)
    • Clinical guidelines for cancer - applying evidence to practice

      O’Toole, Eve; O’Rourke, Niamh; Nolan, Eileen (National Cancer Control Programme (NCCP, 2014)
    • Clinical Guidelines for Cancer - applying evidence to practice [poster]

      O'Toole, Eve; O'Rourke, Niamh; Nolan, E; National Cancer Control Programme (NCCP), Ireland (Health Service Executive, 2014)
    • Community Onocology Nursing Programme: policy, procedures resource book

      National Cancer Control Programme (NCCP); Office of Nursing and Midwifery Services Director (National Cancer Control Programme (NCCP), 2011-03)
    • Delivering care to oncology patients in the community: an innovative integrated approach.

      Hanan, Terry; Mullen, Louise; Laffoy, Marie; O'Toole, Eve; Richmond, Janice; Wynne, Mary (British Journal of Community Nursing, 2014-08)
      A community oncology nursing programme was developed in Ireland between the hospital and community health services for patients receiving systemic cancer therapy, in response to a service need. A robust evaluation of the pilot programme was undertaken, which found that defined clinical procedures traditionally undertaken in hospitals were safely undertaken in the patient's home with no adverse effects. There was a dramatic decrease in hospital attendances for these defined clinical procedures, and hospital capacity was consequently freed up. Patients valued having aspects of their care delivered at home and reported that it improved their quality of life, including reduced hospital visits and travel time. Community nurses expanded their scope of practice and became partners with oncology day-ward nurses in caring for these patients. Community nurses developed the competence and confidence to safely deliver cancer care in the community. This initiative shows that defined elements of acute cancer care can be safely delivered in the community so long as the training and support are provided. The findings and recommendations of the evaluation resulted in university accreditation and approval for national roll-out of the programme. Integration of services between primary and secondary care is a key priority. This innovative programme is a good example of shared integrated care that benefits both patients and health-care providers.