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    Risk of affective disorders following prenatal exposure to severe life events: a Danish population-based cohort study.

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    Authors
    Khashan, Ali S
    McNamee, Roseanne
    Henriksen, Tine B
    Pedersen, Marianne G
    Kenny, Louise C
    Abel, Kathryn M
    Mortensen, Preben B
    Affiliation
    Anu Research Centre, Department of Obstetrics and Gynecology, University College , Cork, Cork University Maternity Hospital, Cork, Ireland. a.khashan@ucc.ie
    Issue Date
    2012-01-31T16:43:12Z
    MeSH
    Adolescent
    Adult
    Aged
    Child
    Cohort Studies
    Cross-Sectional Studies
    Denmark
    Female
    Gestational Age
    Humans
    Infant, Newborn
    *Life Change Events
    Male
    Middle Aged
    Mood Disorders/*epidemiology/*psychology
    Pregnancy
    Prenatal Exposure Delayed Effects/*psychology
    Risk Factors
    Sex Factors
    Young Adult
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    Citation
    J Psychiatr Res. 2011 Jul;45(7):879-85. Epub 2011 Jan 3.
    Journal
    Journal of psychiatric research
    URI
    http://hdl.handle.net/10147/206222
    DOI
    10.1016/j.jpsychires.2010.12.005
    PubMed ID
    21208629
    Abstract
    OBJECTIVE: To examine the effect of prenatal exposure to severe life events on risk of affective disorders in the offspring. METHODS: In a cohort of 1.1 million Danish births from May 1978 until December 1997, mothers were considered exposed if one (or more) of their close relatives died or was diagnosed with serious illness up to 6 months before conception or during pregnancy. Offspring were followed up from their 10th birthday until their death, migration, onset of affective disorder or 31 December 2007; hospital admissions were identified by linkage to the Central Psychiatric Register. Log-linear Poisson regression was used for data analysis. RESULTS: The risk of affective disorders was increased in male offspring whose mothers were exposed to severe life events during the second trimester (adjusted RR 1.55 [95% CI 1.05-2.28]). There was an increased risk of male offspring affective disorders in relation to maternal exposure to death of a relative in the second trimester (adjusted RR 1.74 [95% CI 1.06-2.84]) or serious illness in a relative before pregnancy (adjusted RR 1.44 [95% CI 1.02-2.05]). There was no evidence for an association between prenatal exposure to severe life events and risk of female offspring affective disorders. CONCLUSIONS: Our population-based study suggests that prenatal maternal exposure to severe life events may increase the risk of affective disorders in male offspring. These findings are consistent with studies of populations exposed to famine and earthquake disasters which indicate that prenatal environment may influence the neurodevelopment of the unborn child.
    Language
    eng
    ISSN
    1879-1379 (Electronic)
    0022-3956 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jpsychires.2010.12.005
    Scopus Count
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    Cork University Maternity Hospital

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