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    Early blood glucose profile and neurodevelopmental outcome at two years in neonatal hypoxic-ischaemic encephalopathy.

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    Authors
    Nadeem, Montasser
    Murray, Deirdre M
    Boylan, Geraldine B
    Dempsey, Eugene M
    Ryan, Cornelius A
    Affiliation
    Neonatal Intensive Care Unit, Cork University Maternity Hospital, Cork, Ireland.
    Issue Date
    2012-01-31T16:43:15Z
    MeSH
    Asphyxia Neonatorum/*blood/complications
    Biological Markers
    Birth Weight
    Blood Glucose/*analysis
    Brain Damage, Chronic/*epidemiology/etiology
    Female
    Follow-Up Studies
    Gestational Age
    Humans
    Hyperglycemia/congenital/epidemiology
    Hypoglycemia/complications/congenital/*epidemiology
    Hypothermia, Induced
    Hypoxia-Ischemia, Brain/*blood/complications/therapy
    Infant, Newborn
    Male
    Retrospective Studies
    Time Factors
    Treatment Outcome
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    Citation
    BMC Pediatr. 2011 Feb 4;11:10.
    Journal
    BMC pediatrics
    URI
    http://hdl.handle.net/10147/206223
    DOI
    10.1186/1471-2431-11-10
    PubMed ID
    21294901
    Abstract
    BACKGROUND: To examine the blood glucose profile and the relationship between blood glucose levels and neurodevelopmental outcome in term infants with hypoxic-ischaemic encephalopathy. METHODS: Blood glucose values within 72 hours of birth were collected from 52 term infants with hypoxic-ischaemic encephalopathy. Hypoglycaemia [< 46.8 mg/dL (2.6 mmol/L)] and hyperglycaemia [> 150 mg/dL (8.3 mmol/L)] were correlated to neurodevelopmental outcome at 24 months of age. RESULTS: Four fifths of the 468 blood samples were in the normoglycaemic range (392/468:83.8%). Of the remaining 76 samples, 51.3% were in the hypoglycaemic range and (48.7%) were hyperglycaemic. A quarter of the hypoglycaemic samples (28.2%:11/39) and a third of the hyperglycaemic samples (32.4%:12/37) were recorded within the first 30 minutes of life. Mean (SD) blood glucose values did not differ between infants with normal and abnormal outcomes [4.89(2.28) mmol/L and 5.02(2.35) mmol/L, p value = 0.15] respectively. In term infants with hypoxic-ischaemic encephalopathy, early hypoglycaemia (between 0-6 hours of life) was associated with adverse outcome at 24 months of age [OR = 5.8, CI = 1.04-32)]. On multivariate analysis to adjust for grade of HIE this association was not statistically significant. Late hypoglycaemia (6-72 hours of life) was not associated with abnormal outcome [OR = 0.22, CI (0.04-1.14)]. The occurrence of hyperglycaemia was not associated with adverse outcome. CONCLUSION: During the first 72 hours of life, blood glucose profile in infants with hypoxic-ischaemic encephalopathy varies widely despite a management protocol. Early hypoglycaemia (0-6 hours of life) was associated with severe HIE, and thereby; adverse outcome.
    Language
    eng
    ISSN
    1471-2431 (Electronic)
    1471-2431 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1186/1471-2431-11-10
    Scopus Count
    Collections
    Cork University Maternity Hospital

    entitlement

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