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    Fetal heart rate patterns in neonatal hypoxic-ischemic encephalopathy: relationship with early cerebral activity and neurodevelopmental outcome.

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    Authors
    Murray, Deirdre M
    O'Riordan, Mairead N
    Horgan, Richard
    Boylan, Geraldine
    Higgins, John R
    Ryan, Cornelius A
    Affiliation
    Department of Paediatrics and Child Health, University College Cork, Cork, University Maternity Hospital, Cork, Wilton, Cork, Ireland. d.murray@ucc.ie
    Issue Date
    2012-01-31T16:43:07Z
    MeSH
    *Cardiotocography
    *Child Development
    *Electroencephalography
    Fetal Monitoring
    *Heart Rate, Fetal
    Humans
    Hypoxia-Ischemia, Brain/complications/*physiopathology
    Infant
    Infant, Newborn
    *Neurologic Examination
    Seizures/complications
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    Citation
    Am J Perinatol. 2009 Sep;26(8):605-12. Epub 2009 Apr 27.
    Journal
    American journal of perinatology
    URI
    http://hdl.handle.net/10147/206239
    DOI
    10.1055/s-0029-1220774
    PubMed ID
    19399706
    Abstract
    Despite widespread use of fetal heart rate monitoring, the timing of injury in hypoxic-ischemic encephalopathy (HIE) remains unclear. Our aim was to examine fetal heart rate patterns during labor in infants with clinical and electroencephalographic (EEG) evidence of HIE and to relate these findings to neurodevelopmental outcome. Timing of onset of pathological cardiotocographs (CTGs) was determined in each case by two blinded reviewers and related to EEG grade at birth and neurological outcome at 24 months. CTGs were available in 35 infants with HIE (17 mild, 12 moderate, 6 severe on EEG). Admission CTGs were normal in 24/35 (69%), suspicious in 8/35 (23%), and pathological in 3/35 (8%). All CTGs developed nonreassuring features prior to delivery. Three patterns of fetal heart rate abnormalities were seen: group 1, abnormal CTGs on admission in 11/35 (31%); group 2, normal CTGs on admission with gradual deterioration to pathological in 20/35 cases (57%); and group 3, normal CTGs on admission with acute sentinel events in 4/35 (11.5%). The median (interquartile range) duration between the development of pathological CTGs and delivery was 145 (81, 221) minutes in group 2 and 22 (12, 28) minutes in group 3. There was no correlation between duration of pathological CTG trace and grade of encephalopathy (R = 0.09, P = 0.63) or neurological outcome (P = 0.75). However, the grade of encephalopathy was significantly worse in group 3 (P = 0.001), with a trend to worse outcomes. The majority of infants with HIE have normal CTG traces on admission but develop pathological CTG patterns within hours of delivery. More severe encephalopathy was associated with normal admission CTG and acute sentinel events shortly before delivery.
    Language
    eng
    ISSN
    1098-8785 (Electronic)
    0735-1631 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1055/s-0029-1220774
    Scopus Count
    Collections
    Cork University Maternity Hospital

    entitlement

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