Undiagnosed coeliac disease in a father does not influence birthweight and preterm birth.
AuthorsKhashan, Ali S
Kenny, Louise C
Mortensen, Preben B
Pedersen, Marianne G
McCarthy, Fergus P
Henriksen, Tine B
AffiliationAnu Research Centre, Department of Obstetrics and Gynaecology, University College, Cork, Cork University Maternity Hospital, Ireland. email@example.com
Celiac Disease/diet therapy/*epidemiology
MetadataShow full item record
CitationPaediatr Perinat Epidemiol. 2010 Jul 1;24(4):363-9.
JournalPaediatric and perinatal epidemiology
AbstractThere is conflicting evidence regarding the effect of coeliac disease (CD) in the father on birthweight and preterm birth. We investigated the association between paternal CD and birthweight and preterm birth. Medical records of all singleton live-born children in Denmark between 1 January 1979 and 31 December 2004 were linked to information about parents' diseases. Fathers who were diagnosed with CD were then identified. Fathers with CD were considered treated if they were diagnosed before pregnancy and untreated if they were diagnosed after the date of conception. The outcome measures were: birthweight, small-for-gestational age (birthweight<10th centile for gestational age) and preterm birth (<37 weeks). We compared the offspring of men without CD (n = 1 472 352) and offspring of those with CD [untreated (n = 138) and treated (n = 473)]. There was no significant association between untreated CD in the father and birthweight (adjusted mean difference = -3 g; [95% CI -46, 40]) or preterm birth (adjusted odds ratio (OR) = 0.86, [95% CI 0.53, 1.37]) (compared with no CD). There was some evidence for an association between treated paternal CD and birthweight (adjusted mean difference = -81 g; [95% CI -161, -3]), but not preterm birth (adjusted OR = 1.76, [95% CI 0.95, 3.26]). Untreated paternal CD was not associated with an increased risk of reduced birthweight, or of preterm birth. There was some evidence that diagnosis and presumed treatment of paternal CD with a gluten-free diet is associated with reduced birthweight.
- The impact of maternal celiac disease on birthweight and preterm birth: a Danish population-based cohort study.
- Authors: Khashan AS, Henriksen TB, Mortensen PB, McNamee R, McCarthy FP, Pedersen MG, Kenny LC
- Issue date: 2010 Feb
- Coeliac disease in the father and risk of adverse pregnancy outcome: a population-based cohort study.
- Authors: Ludvigsson JF, Montgomery SM, Ekbom A
- Issue date: 2006 Feb
- Mothers' and fathers' birth characteristics and perinatal mortality in their offspring: a population-based cohort study.
- Authors: Nordtveit TI, Melve KK, Skjaerven R
- Issue date: 2010 May
- Association between congenital toxoplasmosis and preterm birth, low birthweight and small for gestational age birth.
- Authors: Freeman K, Oakley L, Pollak A, Buffolano W, Petersen E, Semprini AE, Salt A, Gilbert R, European Multicentre Study on Congenital Toxoplasmosis.
- Issue date: 2005 Jan
- Prevalence of undiagnosed celiac disease in the parents of preterm and/or small for gestational age infants.
- Authors: Salvatore S, Finazzi S, Radaelli G, Lotzniker M, Zuccotti GV, Premacel Study Group.
- Issue date: 2007 Jan