Undiagnosed coeliac disease in a father does not influence birthweight and preterm birth.
Authors
Khashan, Ali SKenny, Louise C
McNamee, Roseanne
Mortensen, Preben B
Pedersen, Marianne G
McCarthy, Fergus P
Henriksen, Tine B
Affiliation
Anu Research Centre, Department of Obstetrics and Gynaecology, University College, Cork, Cork University Maternity Hospital, Ireland. a.khashan@ucc.ieIssue Date
2012-01-31T16:43:41ZMeSH
Adult*Birth Weight
Celiac Disease/diet therapy/*epidemiology
Denmark/epidemiology
Diet, Gluten-Free
*Fathers
Female
Humans
Infant
Male
Pregnancy
Pregnancy Outcome
Premature Birth/*epidemiology
Young Adult
Metadata
Show full item recordCitation
Paediatr Perinat Epidemiol. 2010 Jul 1;24(4):363-9.Journal
Paediatric and perinatal epidemiologyDOI
10.1111/j.1365-3016.2010.01125.xPubMed ID
20618726Abstract
There is conflicting evidence regarding the effect of coeliac disease (CD) in the father on birthweight and preterm birth. We investigated the association between paternal CD and birthweight and preterm birth. Medical records of all singleton live-born children in Denmark between 1 January 1979 and 31 December 2004 were linked to information about parents' diseases. Fathers who were diagnosed with CD were then identified. Fathers with CD were considered treated if they were diagnosed before pregnancy and untreated if they were diagnosed after the date of conception. The outcome measures were: birthweight, small-for-gestational age (birthweight<10th centile for gestational age) and preterm birth (<37 weeks). We compared the offspring of men without CD (n = 1 472 352) and offspring of those with CD [untreated (n = 138) and treated (n = 473)]. There was no significant association between untreated CD in the father and birthweight (adjusted mean difference = -3 g; [95% CI -46, 40]) or preterm birth (adjusted odds ratio (OR) = 0.86, [95% CI 0.53, 1.37]) (compared with no CD). There was some evidence for an association between treated paternal CD and birthweight (adjusted mean difference = -81 g; [95% CI -161, -3]), but not preterm birth (adjusted OR = 1.76, [95% CI 0.95, 3.26]). Untreated paternal CD was not associated with an increased risk of reduced birthweight, or of preterm birth. There was some evidence that diagnosis and presumed treatment of paternal CD with a gluten-free diet is associated with reduced birthweight.Language
engISSN
1365-3016 (Electronic)0269-5022 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1111/j.1365-3016.2010.01125.x
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