• Login
    View Item 
    •   Home
    • Hospital Research
    • Munster
    • Cork University Maternity Hospital
    • View Item
    •   Home
    • Hospital Research
    • Munster
    • Cork University Maternity Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    5086
    UlsterS
    5086
    Connacht
    1698
    Munster
    58
    Leinster
    466

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Pregnancy and the risk of autoimmune disease.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Khashan, Ali S
    Kenny, Louise C
    Laursen, Thomas M
    Mahmood, Uzma
    Mortensen, Preben B
    Henriksen, Tine B
    O'Donoghue, Keelin
    Affiliation
    Anu Research Centre, Department of Obstetrics and Gynaecology, Cork University, Maternity Hospital, University College Cork, Wilton, Cork, Republic of Ireland.
    Issue Date
    2012-01-31T16:42:57Z
    MeSH
    Adolescent
    Adult
    Autoimmune Diseases/classification/*epidemiology
    Denmark/epidemiology
    Female
    Follow-Up Studies
    Humans
    Male
    Pregnancy
    Risk Factors
    Young Adult
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    PLoS One. 2011;6(5):e19658. Epub 2011 May 18.
    Journal
    PloS one
    URI
    http://hdl.handle.net/10147/206243
    DOI
    10.1371/journal.pone.0019658
    PubMed ID
    21611120
    Abstract
    Autoimmune diseases (AID) predominantly affect women of reproductive age. While basic molecular studies have implicated persisting fetal cells in the mother in some AID, supportive epidemiological evidence is limited. We investigated the effect of vaginal delivery, caesarean section (CS) and induced abortion on the risk of subsequent maternal AID. Using the Danish Civil Registration System (CRS) we identified women who were born between 1960 and 1992. We performed data linkage between the CRS other Danish national registers to identify women who had a pregnancy and those who developed AID. Women were categorised into 4 groups; nulligravida (control group), women who had 1st child by vaginal delivery, whose 1st delivery was by CS and who had abortions. Log-linear Poisson regression with person-years was used for data analysis adjusting for several potential confounders. There were 1,035,639 women aged >14 years and 25,570 developed AID: 43.4% nulligravida, 44.3% had their first pregnancy delivered vaginally, 7.6% CS and 4.1% abortions. The risk of AID was significantly higher in the 1st year after vaginal delivery (RR = 1.1[1.0, 1.2]) and CS (RR = 1.3[1.1, 1.5]) but significantly lower in the 1st year following abortion (RR = 0.7[0.6, 0.9]). These results suggest an association between pregnancy and the risk of subsequent maternal AID. Increased risks of AID after CS may be explained by amplified fetal cell traffic at delivery, while decreased risks after abortion may be due to the transfer of more primitive fetal stem cells. The increased risk of AID in the first year after delivery may also be related to greater testing during pregnancy.
    Language
    eng
    ISSN
    1932-6203 (Electronic)
    1932-6203 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pone.0019658
    Scopus Count
    Collections
    Cork University Maternity Hospital

    entitlement

    Related articles

    • Hyperemesis, gestational hypertensive disorders, pregnancy losses and risk of autoimmune diseases in a Danish population-based cohort.
    • Authors: Jørgensen KT, Nielsen NM, Pedersen BV, Jacobsen S, Frisch M
    • Issue date: 2012 May
    • Pregnancy and the risk of autoimmune disease: An exploration.
    • Authors: O'Donoghue K
    • Issue date: 2011 Jul
    • Ethnic differences in the risk of caesarean section: a Danish population-based register study 2004-2015.
    • Authors: Rasmussen TD, Villadsen SF, Andersen PK, Clausen TD, Nybo Andersen AM
    • Issue date: 2019 Jun 4
    • Risk of breast cancer in relation to reproductive factors in Denmark.
    • Authors: Ewertz M, Duffy SW
    • Issue date: 1988 Jul
    • The effect of pregnancy termination on future reproduction.
    • Authors: Atrash HK, Hogue CJ
    • Issue date: 1990 Jun
    Health Library Ireland | Health Service Executive | Jervis House, Jervis Street | Republic of Ireland | Eircode: D01 W596
    lenus@hse.ie | Tel: +353-1-7786275
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.