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    Animal models of preeclampsia; uses and limitations.

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    Authors
    McCarthy, F P
    Kingdom, J C
    Kenny, L C
    Walsh, S K
    Affiliation
    Anu Research Centre, Department of Obstetrics & Gynaecology, University College, Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland., fergusmccarthy@gmail.com
    Issue Date
    2012-01-31T16:42:35Z
    MeSH
    Animals
    *Disease Models, Animal
    Female
    Humans
    *Pre-Eclampsia
    Pregnancy
    
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    Citation
    Placenta. 2011 Jun;32(6):413-9. Epub 2011 Apr 17.
    Journal
    Placenta
    URI
    http://hdl.handle.net/10147/206251
    DOI
    10.1016/j.placenta.2011.03.010
    PubMed ID
    21497901
    Abstract
    Preeclampsia remains a leading cause of maternal and fetal morbidity and mortality and has an unknown etiology. The limited progress made regarding new treatments to reduce the incidence and severity of preeclampsia has been attributed to the difficulties faced in the development of suitable animal models for the mechanistic research of this disease. In addition, animal models need hypotheses on which to be based and the slow development of testable hypotheses has also contributed to this poor progress. The past decade has seen significant advances in our understanding of preeclampsia and the development of viable reproducible animal models has contributed significantly to these advances. Although many of these models have features of preeclampsia, they are still poor overall models of the human disease and limited due to lack of reproducibility and because they do not include the complete spectrum of pathophysiological changes associated with preeclampsia. This review aims to provide a succinct and comprehensive assessment of current animal models of preeclampsia, their uses and limitations with particular attention paid to the best validated and most comprehensive models, in addition to those models which have been utilized to investigate potential therapeutic interventions for the treatment or prevention of preeclampsia.
    Language
    eng
    ISSN
    1532-3102 (Electronic)
    0143-4004 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.placenta.2011.03.010
    Scopus Count
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    Cork University Maternity Hospital

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