AuthorsMcNicholas, Walter T
AffiliationSleep Research Laboratory, St. Vincent's University Hospital, Dublin, Ireland., firstname.lastname@example.org
Cell Adhesion Molecules/metabolism
Sleep Apnea, Obstructive/complications/*immunology
Tumor Necrosis Factor-alpha/metabolism
MetadataShow full item record
CitationProg Cardiovasc Dis. 2009 Mar-Apr;51(5):392-9.
JournalProgress in cardiovascular diseases
AbstractThe pathogenesis of cardiovascular complications in obstructive sleep apnea syndrome (OSAS) is not fully understood but is likely multifactorial in origin. Inflammatory processes play an important role in the pathogenesis of atherosclerosis, and circulating levels of several markers of inflammation have been associated with future cardiovascular risk. These include cell adhesion molecules such as intercellular adhesion molecule-1 and selectins, cytokines such as tumour necrosis factor alpha and interleukin 6, chemokines such as interleukin 8, and C-reactive protein. There is also increasing evidence that inflammatory processes play an important role in the cardiovascular pathophysiology of OSAS and many of the inflammatory markers associated with cardiovascular risk have been reported as elevated in patients with OSAS. Furthermore, animal and cell culture studies have demonstrated preferential activation of inflammatory pathways by intermittent hypoxia, which is an integral feature of OSAS. The precise role of inflammation in the development of cardiovascular disease in OSAS requires further study, particularly the relationship with oxidative stress, metabolic dysfunction, and obesity.
- Obstructive sleep apnea and inflammation: relationship to cardiovascular co-morbidity.
- Authors: Kent BD, Ryan S, McNicholas WT
- Issue date: 2011 Sep 30
- Inflammatory cardiovascular risk markers in obstructive sleep apnoea syndrome.
- Authors: Ryan S, McNicholas WT
- Issue date: 2009 Jan
- Systemic inflammation: a key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome?
- Authors: Ryan S, Taylor CT, McNicholas WT
- Issue date: 2009 Jul
- The role inflammatory response genes in obstructive sleep apnea syndrome: a review.
- Authors: de Lima FF, Mazzotti DR, Tufik S, Bittencourt L
- Issue date: 2016 Mar
- Obstructive sleep apnea syndrome and upper airway inflammation.
- Authors: Inancli HM, Enoz M
- Issue date: 2010 Jan