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dc.contributor.authorRyan, C
dc.contributor.authorWhittaker, S
dc.contributor.authorD'Arcy, C
dc.contributor.authorO'Regan, G M
dc.contributor.authorRogers, S
dc.date.accessioned2012-02-01T10:32:21Z
dc.date.available2012-02-01T10:32:21Z
dc.date.issued2012-02-01T10:32:21Z
dc.identifier.citationClin Exp Dermatol. 2009 Jul;34(5):e160-2. Epub 2008 Dec 15.en_GB
dc.identifier.issn1365-2230 (Electronic)en_GB
dc.identifier.issn0307-6938 (Linking)en_GB
dc.identifier.pmid19094122en_GB
dc.identifier.doi10.1111/j.1365-2230.2008.03051.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207594
dc.description.abstractIchthyosiform mycosis fungoides (MF) is a recently recognized clinical variant of MF, which appears as dry scaling patches and plaques, or as a generalized eruption. Acquired ichthyosis is well recognized as a paraneoplastic cutaneous presentation of malignancy, especially in lymphoproliferative disorders. In contrast, the ichthyosiform eruption in ichthyotic MF is attributable to infiltration of the skin by tumour cells. We report the case of a 15-year-old boy who presented with a 5-year history of enlarging pruritic plaques on the forehead and back, patchy alopecia and generalized ichthyosis. Histology of the forehead and back showed a dense, lymphocytic, folliculocentric and perivascular infiltrate of predominantly CD4-positive T cells consistent with folliculotropic MF. Histological examination of biopsies from ichthyotic skin found similar features. Our patient had a histological diagnosis at the age of 15 years, making him the youngest reported patient with either folliculotropic MF or ichthyotic MF.
dc.language.isoengen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshHair Follicle/pathologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIchthyosis/*pathologyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMycosis Fungoides/*pathologyen_GB
dc.subject.meshNeoplasm Invasivenessen_GB
dc.subject.meshSkin Neoplasms/*pathologyen_GB
dc.titleJuvenile folliculotropic and ichthyosiform mycosis fungoides.en_GB
dc.contributor.departmentDepartment of Dermatology, St Vincent's University Hospital, Elm Park, Dublin,, Ireland. caitrionaryan80@hotmail.comen_GB
dc.identifier.journalClinical and experimental dermatologyen_GB
dc.description.provinceLeinster
html.description.abstractIchthyosiform mycosis fungoides (MF) is a recently recognized clinical variant of MF, which appears as dry scaling patches and plaques, or as a generalized eruption. Acquired ichthyosis is well recognized as a paraneoplastic cutaneous presentation of malignancy, especially in lymphoproliferative disorders. In contrast, the ichthyosiform eruption in ichthyotic MF is attributable to infiltration of the skin by tumour cells. We report the case of a 15-year-old boy who presented with a 5-year history of enlarging pruritic plaques on the forehead and back, patchy alopecia and generalized ichthyosis. Histology of the forehead and back showed a dense, lymphocytic, folliculocentric and perivascular infiltrate of predominantly CD4-positive T cells consistent with folliculotropic MF. Histological examination of biopsies from ichthyotic skin found similar features. Our patient had a histological diagnosis at the age of 15 years, making him the youngest reported patient with either folliculotropic MF or ichthyotic MF.


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