Meta-analysis of timolol on diurnal and nighttime intraocular pressure and blood pressure.
AuthorsLee, Princeton Wen-Yuan
Stewart, Jeanette A
Kristoffersen, Caroline J
Stewart, William C
AffiliationRoyal Victoria Eye and Ear Hospital, Dublin, Ireland.
Adrenergic beta-Antagonists/*administration & dosage
Blood Pressure/*drug effects/physiology
Circadian Rhythm/*drug effects/physiology
Glaucoma, Open-Angle/*drug therapy/physiopathology
Intraocular Pressure/*drug effects/physiology
Ocular Hypertension/drug therapy/physiopathology
Ophthalmic Solutions/administration & dosage
Randomized Controlled Trials as Topic
Timolol/*administration & dosage
MetadataShow full item record
CitationEur J Ophthalmol. 2010 Nov-Dec;20(6):1035-41.
JournalEuropean journal of ophthalmology
AbstractPURPOSE: To evaluate the nighttime intraocular pressure (IOP) and blood pressure (BP) response to timolol treatment in patients with ocular hypertension or primary open-angle glaucoma. METHODS: This was a meta-analysis of previously published studies that must have been randomized, prospective, crossover or parallel, single or double-masked trials. The treatment period must have been >/=2 weeks with >/=19 patients per treatment arm for a crossover, and >/=50 patients for a parallel designed trial. Studies must have included both baseline and treated 24-hour curves. RESULTS: For the IOP analysis, we included 8 articles with 340 patients. A reduction from baseline was observed for timolol at each time point and for the 24-hour curve (p0.05). CONCLUSIONS: This meta-analysis suggests that topical timolol therapy provides an ocular hypotensive effect over the 24-hour curve, including the nighttime hours, and while small reductions in the systolic and diastolic pressures occur, the ocular perfusion pressure is not altered over 24 hours.