Risk factors, microbiological findings, and clinical outcomes in cases of microbial keratitis admitted to a tertiary referral center in ireland.
AffiliationWaterford Regional Hospital, Waterford, Ireland. firstname.lastname@example.org
Anti-Bacterial Agents/therapeutic use
Antiprotozoal Agents/therapeutic use
Eye Infections, Bacterial/diagnosis/*microbiology/therapy
Eye Infections, Fungal/diagnosis/*microbiology/therapy
Ophthalmologic Surgical Procedures
Referral and Consultation
MetadataShow full item record
CitationCornea. 2009 Apr;28(3):285-92.
AbstractAIM: To identify the risk factors for, and to report the microbiological findings and clinical outcomes of, severe microbial keratitis (MK). METHODS: This was a retrospective study of all cases of presumed MK admitted to a tertiary referral center over a 2-year period (September 2001 to August 2003). Data recorded included demographic data, details relating to possible risk factors, results of microbiological studies, clinical findings at presentation, and clinical and visual outcomes. RESULTS: Ninety patients were admitted with a diagnosis of presumed MK during the study period. The mean age of patients was 45 +/- 32 years, and the male to female ratio was 47:43 (52.2%:47.7%). Predisposing risk factors for MK included contact lens wear (37; 41.1%), anterior segment disease (19; 21.1%), ocular trauma (13; 14.4%), systemic disease (5; 5.6%), and previous ocular surgery (1; 1.1%). Cultured organisms included gram-negative bacteria (17; 51.5%), gram-positive bacteria (11, 33.3%), acanthamoeba (2; 6.1%), and fungi (1; 3%). Visual acuity improved significantly after treatment [mean best-corrected visual acuity (+/-standard deviation) at presentation: 0.76 (+/-0.11); mean best-corrected visual acuity at last follow-up: 0.24 (+/-0.07); P < 0.001]. Secondary surgical procedures were required in 18 (20%) cases, and these included punctal cautery (1; 1.1%), tissue glue repair of corneal perforation (2; 2.2%), tarsorrhaphy (9; 9.9%), Botulinum toxin-induced ptosis (1; 1.1%), penetrating keratoplasty (3; 3.3%), and evisceration (2; 2.2%). CONCLUSIONS: Contact lens wear remains a significant risk factor for severe MK. MK remains a threat to vision and to the eye, but the majority of cases respond to prompt and appropriate antimicrobial therapy.
- Risk factors and causative organisms in microbial keratitis.
- Authors: Green M, Apel A, Stapleton F
- Issue date: 2008 Jan
- Microbial keratitis predisposing factors and morbidity.
- Authors: Keay L, Edwards K, Naduvilath T, Taylor HR, Snibson GR, Forde K, Stapleton F
- Issue date: 2006 Jan
- Predisposing factors and etiologic diagnosis of ulcerative keratitis.
- Authors: Sirikul T, Prabriputaloong T, Smathivat A, Chuck RS, Vongthongsri A
- Issue date: 2008 Apr
- Risk factors in microbial keratitis leading to penetrating keratoplasty.
- Authors: Miedziak AI, Miller MR, Rapuano CJ, Laibson PR, Cohen EJ
- Issue date: 1999 Jun
- Outcome of treated orbital cellulitis in a tertiary eye care center in the middle East.
- Authors: Chaudhry IA, Shamsi FA, Elzaridi E, Al-Rashed W, Al-Amri A, Al-Anezi F, Arat YO, Holck DE
- Issue date: 2007 Feb