• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • Coombe Women & Infants University Hospital
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • Coombe Women & Infants University Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4715
    UlsterS
    4715
    Connacht
    1603
    Munster
    48
    Leinster
    426

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementRIAN Pathways to Irish ResearchHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Display statistics

    Methadone dose and neonatal abstinence syndrome-systematic review and meta-analysis.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Cleary, Brian J
    Donnelly, Jean
    Strawbridge, Judith
    Gallagher, Paul J
    Fahey, Tom
    Clarke, Mike
    Murphy, Deirdre J
    Affiliation
    Coombe Women and Infants University Hospital, Dublin 8, Ireland School of, Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland., bcleary@coombe.ie
    Issue Date
    2012-02-01T10:58:32Z
    MeSH
    Cohort Studies
    Databases, Bibliographic
    Dose-Response Relationship, Drug
    Female
    Humans
    Infant, Newborn
    Methadone/*administration & dosage/adverse effects
    Narcotics/*administration & dosage/adverse effects
    Neonatal Abstinence Syndrome/*epidemiology/etiology
    Opioid-Related Disorders/*drug therapy
    Pregnancy
    Pregnancy Complications/*drug therapy
    Prenatal Exposure Delayed Effects
    Randomized Controlled Trials as Topic
    Severity of Illness Index
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Addiction. 2010 Dec;105(12):2071-84. doi: 10.1111/j.1360-0443.2010.03120.x. Epub , 2010 Sep 15.
    Journal
    Addiction (Abingdon, England)
    URI
    http://hdl.handle.net/10147/208042
    DOI
    10.1111/j.1360-0443.2010.03120.x
    PubMed ID
    20840198
    Abstract
    AIM: To determine if there is a relationship between maternal methadone dose in pregnancy and the diagnosis or medical treatment of neonatal abstinence syndrome (NAS). METHODS: PubMed, EMBASE, the Cochrane Library and PsychINFO were searched for studies reporting on methadone use in pregnancy and NAS (1966-2009). The relative risk (RR) of NAS was compared for methadone doses above versus below a range of cut-off points. Summary RRs and 95% confidence intervals (CI) were estimated using random effects meta-analysis. Sensitivity analyses explored the impact of limiting meta-analyses to prospective studies or studies using an objective scoring system to diagnose NAS. RESULTS: A total of 67 studies met inclusion criteria for the systematic review; 29 were included in the meta-analysis. Any differences in the incidence of NAS in infants of women on higher compared with lower doses were statistically non-significant in analyses restricted to prospective studies or to those using an objective scoring system to diagnose NAS. CONCLUSIONS: Severity of the neonatal abstinence syndrome does not appear to differ according to whether mothers are on high- or low-dose methadone maintenance therapy.
    Language
    eng
    ISSN
    1360-0443 (Electronic)
    0965-2140 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1360-0443.2010.03120.x
    Scopus Count
    Collections
    Coombe Women & Infants University Hospital

    entitlement

     
    National Health Library & Knowledge Service | Health Service Executive | Dr Steevens' Hospital | Dublin 8 | Ireland
    lenus@hse.ie | Tel +353 (1) 6352558
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.