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dc.contributor.authorCleary, Brian J
dc.contributor.authorDonnelly, Jean
dc.contributor.authorStrawbridge, Judith
dc.contributor.authorGallagher, Paul J
dc.contributor.authorFahey, Tom
dc.contributor.authorClarke, Mike
dc.contributor.authorMurphy, Deirdre J
dc.date.accessioned2012-02-01T10:58:32Z
dc.date.available2012-02-01T10:58:32Z
dc.date.issued2012-02-01T10:58:32Z
dc.identifier.citationAddiction. 2010 Dec;105(12):2071-84. doi: 10.1111/j.1360-0443.2010.03120.x. Epub , 2010 Sep 15.en_GB
dc.identifier.issn1360-0443 (Electronic)en_GB
dc.identifier.issn0965-2140 (Linking)en_GB
dc.identifier.pmid20840198en_GB
dc.identifier.doi10.1111/j.1360-0443.2010.03120.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/208042
dc.description.abstractAIM: To determine if there is a relationship between maternal methadone dose in pregnancy and the diagnosis or medical treatment of neonatal abstinence syndrome (NAS). METHODS: PubMed, EMBASE, the Cochrane Library and PsychINFO were searched for studies reporting on methadone use in pregnancy and NAS (1966-2009). The relative risk (RR) of NAS was compared for methadone doses above versus below a range of cut-off points. Summary RRs and 95% confidence intervals (CI) were estimated using random effects meta-analysis. Sensitivity analyses explored the impact of limiting meta-analyses to prospective studies or studies using an objective scoring system to diagnose NAS. RESULTS: A total of 67 studies met inclusion criteria for the systematic review; 29 were included in the meta-analysis. Any differences in the incidence of NAS in infants of women on higher compared with lower doses were statistically non-significant in analyses restricted to prospective studies or to those using an objective scoring system to diagnose NAS. CONCLUSIONS: Severity of the neonatal abstinence syndrome does not appear to differ according to whether mothers are on high- or low-dose methadone maintenance therapy.
dc.language.isoengen_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshDatabases, Bibliographicen_GB
dc.subject.meshDose-Response Relationship, Drugen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfant, Newbornen_GB
dc.subject.meshMethadone/*administration & dosage/adverse effectsen_GB
dc.subject.meshNarcotics/*administration & dosage/adverse effectsen_GB
dc.subject.meshNeonatal Abstinence Syndrome/*epidemiology/etiologyen_GB
dc.subject.meshOpioid-Related Disorders/*drug therapyen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshPregnancy Complications/*drug therapyen_GB
dc.subject.meshPrenatal Exposure Delayed Effectsen_GB
dc.subject.meshRandomized Controlled Trials as Topicen_GB
dc.subject.meshSeverity of Illness Indexen_GB
dc.titleMethadone dose and neonatal abstinence syndrome-systematic review and meta-analysis.en_GB
dc.contributor.departmentCoombe Women and Infants University Hospital, Dublin 8, Ireland School of, Pharmacy, Royal College of Surgeons in Ireland, Dublin 2, Ireland., bcleary@coombe.ieen_GB
dc.identifier.journalAddiction (Abingdon, England)en_GB
dc.description.provinceLeinster
html.description.abstractAIM: To determine if there is a relationship between maternal methadone dose in pregnancy and the diagnosis or medical treatment of neonatal abstinence syndrome (NAS). METHODS: PubMed, EMBASE, the Cochrane Library and PsychINFO were searched for studies reporting on methadone use in pregnancy and NAS (1966-2009). The relative risk (RR) of NAS was compared for methadone doses above versus below a range of cut-off points. Summary RRs and 95% confidence intervals (CI) were estimated using random effects meta-analysis. Sensitivity analyses explored the impact of limiting meta-analyses to prospective studies or studies using an objective scoring system to diagnose NAS. RESULTS: A total of 67 studies met inclusion criteria for the systematic review; 29 were included in the meta-analysis. Any differences in the incidence of NAS in infants of women on higher compared with lower doses were statistically non-significant in analyses restricted to prospective studies or to those using an objective scoring system to diagnose NAS. CONCLUSIONS: Severity of the neonatal abstinence syndrome does not appear to differ according to whether mothers are on high- or low-dose methadone maintenance therapy.


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