Medication use in early pregnancy-prevalence and determinants of use in a prospective cohort of women.
AuthorsCleary, Brian J
Strawbridge, Judith D
Gallagher, Paul J
Murphy, Deirdre J
AffiliationCoombe Women and Infants University Hospital, Dublin, Republic of Ireland., email@example.com
Drug Utilization Review/*statistics & numerical data
Fetal Development/drug effects
*Pharmaceutical Preparations/administration & dosage/adverse
Plant Preparations/administration & dosage/adverse effects/therapeutic use
Pregnancy Complications/*drug therapy/epidemiology/etiology
Prescription Drugs/administration & dosage/adverse effects/therapeutic use
Street Drugs/adverse effects
United States Food and Drug Administration
MetadataShow full item record
CitationPharmacoepidemiol Drug Saf. 2010 Apr;19(4):408-17.
JournalPharmacoepidemiology and drug safety
AbstractPURPOSE: To examine the extent, nature and determinants of medication use in early pregnancy. METHODS: We reviewed early pregnancy medication use, as reported to a midwife at the booking interview, in women delivering between 2000 and 2007 in a large maternity hospital in Dublin, Ireland (n = 61 252). RESULTS: Excluding folic acid, at least one medication was reported in 23 989 (39.2%) pregnancies. Over the counter (OTC) medications were reported in 11 970 (19.5%) pregnancies, illicit drugs or methadone in 545 (0.9%) and herbal medicines/supplements in 352 (0.58%). FDA category D and X medications were reported by 1532 (2.5%) and 1987 (3.2%) women. Asthma, depression and hypertension were among the most commonly reported chronic medical disorders. Medications with potential for foetal harm were reported by 86 (15.7%) women treated for depression and 68 (20%) women treated for hypertension. Factors associated with reporting the use of medications with potential for foetal harm included unplanned pregnancy (adjusted odds ratio [aOR] 1.31, 95% confidence interval [CI] 1.12-1.52), booking at less than 12 weeks gestation (aOR 1.83, 95%CI 1.58-2.13), being above 25 years of age, unemployed (aOR 2.58, 95%CI 2.03-3.29), nulliparous (aOR 1.41; 95%CI 1.22-1.63), single (aOR 1.28; 95%CI 1.06-1.54) or smoking during pregnancy (aOR 1.96, 95%CI 1.67-2.28). CONCLUSIONS: Women frequently report medication use in early pregnancy. Women and prescribers need to be aware of the lack of pregnancy safety data for many medications, and the need for pre-pregnancy planning. Prescribers should ensure that optimal medications are used when treating women of childbearing potential with chronic medical disorders.
- Maternal characteristics associated with pregnancy exposure to FDA category C, D, and X drugs in a Canadian population.
- Authors: Yang T, Walker MC, Krewski D, Yang Q, Nimrod C, Garner P, Fraser W, Olatunbosun O, Wen SW
- Issue date: 2008 Mar
- Use of over-the-counter medications and herbal remedies in pregnancy.
- Authors: Refuerzo JS, Blackwell SC, Sokol RJ, Lajeunesse L, Firchau K, Kruger M, Sorokin Y
- Issue date: 2005 Aug
- Prevalence and predictors of periconceptional folic acid uptake--prospective cohort study in an Irish urban obstetric population.
- Authors: McGuire M, Cleary B, Sahm L, Murphy DJ
- Issue date: 2010 Feb
- Provision of potentially teratogenic medications to female veterans of childbearing age.
- Authors: Schwarz EB, Longo LS, Zhao X, Stone RA, Cunningham F, Good CB
- Issue date: 2010 Sep
- Unemployment and pregnancy outcomes: a study within the Danish National Birth Cohort.
- Authors: Morales-Suárez-Varela M, Kaerlev L, Zhu JL, Bonde JP, Nohr EA, Llopis-González A, Gimeno-Clemente N, Olsen J
- Issue date: 2011 Jul