Recent Submissions

  • Metabolomic Workflow for the Accurate and High-Throughput Exploration of the Pathways of Tryptophan, Tyrosine, Phenylalanine, and Branched-Chain Amino Acids in Human Biofluids.

    Anesi, Andrea; Berding, Kirsten; Clarke, Gerard; Stanton, Catherine; Cryan, John F; Caplice, Noel; Ross, R Paul; Doolan, Andrea; Vrhovsek, Urska; Mattivi, Fulvio (2022-04-05)
  • Phage-mediated horizontal gene transfer and its implications for the human gut microbiome.

    Borodovich, Tatiana; Shkoporov, Andrey N; Ross, R Paul; Hill, Colin (2022-04-13)
  • A Video-Based Behavioral Intervention Associated with Improved HPV Knowledge and Intention to Vaccinate.

    Marshall, Sarah; Moore, Anne C; Fleming, Aoife; Sahm, Laura J (2022-04-05)
    The aim of this study was to design, develop, and evaluate the feasibility of a theory- and evidence-based intervention to improve human papillomavirus (HPV) and HPV vaccine knowledge and intention to vaccinate, among parent-daughter dyads. A theory- and evidence-based online behavioral intervention, "Is the HPV vaccine for me?", was developed to improve HPV and HPV vaccine knowledge and intention to vaccinate. Knowledge, intention to vaccinate, and feasibility of the intervention were evaluated in a prospective, randomized, controlled feasibility trial. A total of 49 parent-daughter dyads completed the baseline knowledge assessment (n = 24 control, n = 25 intervention), and 35 dyads completed the knowledge assessment at week 2 (n = 17 control, n = 18 intervention). The intervention resulted in a statistically significant increase in HPV and HPV vaccine knowledge and intention to vaccinate. All intervention participants found the video interesting, while 96% found it useful. This intervention was found to be useful, effective, safe, and acceptable in this feasibility study.
  • A frameshift in time.

    Yordanova, Martina M; Baranov, Pavel V (2022-04-11)
  • COVID-19 IDD: Findings from a global survey exploring family members' and paid staff's perceptions of the impact of COVID-19 on individuals with intellectual and developmental disabilities (IDD) and their caregivers.

    Linehan, Christine; Birkbeck, Gail; Araten-Bergman, Tal; Baumbusch, Jennifer; Beadle-Brown, Julie; Bigby, Christine; Bradley, Valerie; Brown, Michael; Bredewold, Femmianne; Chirwa, Masauso; et al. (2022-04-04)
    Background: A growing body of evidence attests to the disproportionate impact of COVID-19 on persons with intellectual and developmental disabilities (IDD) during the pandemic. This study asked caregivers about their perceptions of how COVID-19 impacted them and the people they support. Method: An online survey was conducted in 12 countries during August-September 2020 and sought information on demographics, support practices, information and training, experiences of COVID-19, social distancing, and wellbeing, as measured by the DASS12. This study reports on 3,754 family members, direct support professionals, and managers who participated in the survey. Results: Caregivers observed increases in depression/anxiety, stereotyped behaviours, aggression towards others and weight gain in the person(s) they supported. They also reported difficulties supporting the person(s) to access healthcare.  Families reported reducing or ceasing employment and absorbed additional costs when supporting their family member. Direct support professionals experienced changes in staff shifts, staff absences, increased workload and hiring of casual staff. Caregivers' wellbeing revealed high levels of stress, depression, and less so anxiety. The strongest predictor of wellbeing among families was observation of changes in mood in the person(s) they supported, while for direct support professionals, the strongest predictors of wellbeing were reorganisation of staff shifts and increases in new direct support staff.  Discussion: Findings support the contention of this population experiencing a disproportionate burden during the COVID-19 pandemic, reflecting historical inequities in access to healthcare and other human rights violations which are now protected under the United Nations Convention on the Rights of Persons with Disabilities.
  • Data Evolution in Times of Crisis: an Organisational Mindfulness Perspective.

    Flynn, Ger; Nagle, Tadhg; Fitzgerald, Ciara (2022-04-29)
  • Taxonomic and Functional Fecal Microbiota Signatures Associated With Insulin Resistance in Non-Diabetic Subjects With Overweight/Obesity Within the Frame of the PREDIMED-Plus Study.

    Atzeni, Alessandro; Bastiaanssen, Thomaz F S; Cryan, John F; Tinahones, Francisco J; Vioque, Jesús; Corella, Dolores; Fitó, Montserrat; Vidal, Josep; Moreno-Indias, Isabel; Gómez-Pérez, Ana M; et al. (2022-04-28)
    Desulfovibrio, Odoribacter and Oscillospiraceae UCG-002 were negatively associated with HOMA-IR index, whereas predicted total functional abundances revealed gut metabolic modules mainly linked to amino acid degradation. Butyricicoccus, Erysipelotrichaceae UCG-003, Faecalibacterium were positively associated with HOMA-IR index, whereas predicted total functional abundances revealed gut metabolic modules mainly linked to saccharide degradation. These bacteria contribute differentially to the gut metabolic modules, being the degree of contribution dependent on insulin resistance. Both taxa and gut metabolic modules negatively associated to HOMA-IR index were linked to mechanisms involving sulfate reducing bacteria, improvement of intestinal gluconeogenesis and production of acetate. Furthermore, both taxa and gut metabolic modules positively associated to HOMA-IR index were linked to production and mechanisms of action of butyrate.
  • DBSCAN-SWA: An Integrated Tool for Rapid Prophage Detection and Annotation.

    Gan, Rui; Zhou, FengXia; Si, Yu; Yang, Han; Chen, Chuangeng; Ren, Chunyan; Wu, Jiqiu; Zhang, Fan (2022-04-19)
  • Evaluations of postoperative transitions in care for older adults: a scoping review.

    Hladkowicz, Emily; Dumitrascu, Flavia; Auais, Mohammad; Beck, Andrew; Davis, Sascha; McIsaac, Daniel I; Miller, Jordan (2022-04-15)
  • Prevalence of mental health disorders in children and adolescents in the Republic of Ireland: a systematic review.

    Lynch, S; McDonnell, Thérèse; Leahy, D; Gavin, B; McNicholas, F (2022-10-26)
  • Oxidative Status in Adult Anorexia Nervosa Patients and Healthy Controls-Results from a Cross-Sectional Pilot Study.

    Wagner-Skacel, Jolana; Haidacher, Fiona; Wiener, Markus; Pahsini, Karoline; Marinschek, Sabine; Lahousen, Theresa; Wonisch, Willibald; Bengesser, Susanne; Butler, Mary I; Lackner, Sonja; et al. (2022-04-26)
    Oxidative stress describes an imbalance of reactive oxygen species (ROS) and antioxidative defence systems. Recently, the consequences of oxidative stress have become a central field of research and have been linked to the genesis of multiple psychiatric diseases. Some oxidative stress parameters have not been investigated before in anorexia nervosa (AN) patients, including the gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) and polyphenols (PPm). In this cross-sectional pilot study, we evaluated these markers together with total peroxides (TOC), antioxidative capacity (TAC), endogenous peroxidase activity (EPA) and antibodies against oxidized LDL (oLAb) in serum samples of 20 patients with AN compared to 20 healthy controls. The antioxidative capacity was significantly decreased in AN patients, with a mean TAC of 1.57 mmol/L (SD: ±0.62); t (34) = -2.181, p = 0.036) compared to HC (mean = 1.91 mmol/L (SD: ±0.56), while the other investigated parameters were not significantly different between the two groups. In AN patients, TAC correlated with EPA (rsp = -0.630, p = 0.009). This study suggests that there is an antioxidative deficiency in AN patients. In this respect, there is a demand for interventional studies to determine whether antioxidants can be used as add-on therapy in the treatment of AN.
  • Effects of novel glucose-lowering drugs on the lipid parameters: A systematic review and meta-analysis.

    Dar, Sophia; Siddiqi, Ahmed Kamal; Alabduladhem, Tamim Omar; Rashid, Ahmed Mustafa; Sarfraz, Saba; Maniya, Talha; Menezes, Ritesh G; Almas, Talal (2022-04-16)
  • COVID-19 vaccine hesitancy and influence of professional medical guidance.

    Nair, Govind; Venkatesan, Kirthika; Nair, Arjun; Firoz, Irene N; Haroon, Nisha Nigil (2022-04-28)
    Results revealed that participants who attended the webinar reported greater confidence in receiving the COVID-19 vaccine. There was a statistically significant difference between pre- and postwebinar confidence scores for the COVID-19 vaccine, χ2 (12, n = 80) = 43.34, P < 0.01.
  • The evaluation of a training course to enhance intellectual disabilities and mental health awareness amongst General Practitioners attending police stations.

    Gulati, Gautam; Murphy, Valerie; Brar, Gurjot; Kilcommins, Shane; Cusack, Alan; Dunne, Colum P; Glynn, Liam; Kelly, Brendan D (2022-05-13)
  • Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment.

    Rhodes, Johanna; Abdolrasouli, Alireza; Dunne, Katie; Sewell, Thomas R; Zhang, Yuyi; Ballard, Eloise; Brackin, Amelie P; van Rhijn, Norman; Chown, Harry; Tsitsopoulou, Alexandra; et al. (2022-04-25)
  • Safety and efficacy of direct oral anticoagulants in comparison with warfarin across different BMI ranges: A systematic review and meta-analysis.

    Almas, Talal; Muhammad, Faeez; Siddiqui, Laiba; Shafi, Batool; Gul, Rabbia; Altaf, Rafiya; Abbasi, Zaeem; Mustafa, Ghulam; Iqbal, Arham; Durdana, Amatul Rehman; et al. (2022-04-14)
    In our first comparison, 12 studies (n = 254,908 patients) were included. For our second comparison, six studies (n = 109,609 patients) were included. Major bleeding events in the underweight group were higher than normal weight [RR: 1.89 (1.10, 3.23); P = 0.02; I 2  = 0%]. Overweight patients were related with reduced rates of VTE than in patients with normal BMI [RR: 0.86 (0.76, 0.97); P = 0.02; I 2  = 0%]. In comparison with patients receiving warfarin, DOACs had significantly reduced risk of major bleeding in normal weight, overweight and obese [OR: 0.64 (0.49, 0.83); P = 0.0007 I 2  = 90%].
  • SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration.

    Gibbons, Luke; Ozaki, Ema; Greene, Chris; Trappe, Anne; Carty, Michael; Coppinger, Judith A; Bowie, Andrew G; Campbell, Matthew; Doyle, Sarah L (2022-04-01)
    SARM1 (sterile alpha and armadillo motif-containing protein) is a highly conserved Toll/IL-1 Receptor (TIR) adaptor with important roles in mediating immune responses. Studies in the brain have shown that SARM1 plays a role in induction of neuronal axon degeneration in response to a variety of injuries. We recently demonstrated that SARM1 is pro-degenerative in a genetic model of inherited retinopathy. This current study aimed to characterise the effect of SARM1 deletion in an alternative model of retinal degeneration (RD) in which the retinal pigment epithelium (RPE) fragments following administration of oxidising agent, sodium iodate (NaIO3), leading to subsequent photoreceptor cell death. Following administration of NaIO3, we observed no apparent difference in rate of loss of RPE integrity in SARM1 deficient mice compared to WT counterparts. However, despite no differences in RPE degeneration, photoreceptor cell number and retinal thickness were increased in Sarm1-/- mice compared to WT counterparts. This apparent protection of the photoreceptors in SARM1 deficient mice is supported by an observed decrease in pro-apoptotic caspase-3 in the photoreceptor layer of Sarm1-/- mice compared to WT. Together these data indicate a pro-degenerative role for SARM1 in the photoreceptors, but not in the RPE, in an oxidative stress induced model of retinal degeneration consistent with its known degenerative role in neurons in a range of neurodegenerative settings.
  • Clinical Characteristics and Distribution of Pediatric Fractures at a Tertiary Hospital in Northern France: A 20-Year-Distance Comparative Analysis (1999-2019).

    Monget, Faustine; Sapienza, Marco; McCracken, Kathryn Louise; Nectoux, Eric; Fron, Damien; Andreacchio, Antonio; Pavone, Vito; Canavese, Federico (2022-04-28)
    Background and objectives: The epidemiology and distribution of pediatric fractures change over time and are influenced by a multitude of factors including geography, climate, and population characteristics. The aims of our work were to study the distribution of traumatic pediatric orthopedic injuries admitted to the Lille University Hospital (LUH) Pediatric Emergency Department in 1999 and in 2019 and to analyze the epidemiological differences 20 years apart. Materials and methods: This was a retrospective, comparative, monocentric, and epidemiological study involving all children between 0 and 15 years and 3 months of age who consulted the pediatric emergencies of LUH from 1 January 1999 to 31 December 1999 and from 1 January 2019 to 31 December 2019. On admission, the following data were collected: sex, age at the time of injury, month and time of the day the trauma occurred (4:00 a.m to 11:59 a.m, 12:00 p.m. to 19:59 p.m, and 20:00 p.m to 3:59 a.m.), mechanism of injury, laterality (right or left), anatomical location, type of injury, and whether the fracture was closed or open. The type of treatment (orthopedic or surgical) was collected from the medical records. Results: A total of 939 children were included in 1999 compared with 781 in 2019 (21% decrease); the average age of children with fractures was significantly higher in 1999 (8.81 years) than in 2019 (7.19 years). This difference was explained by the majority involvement of older children (10-15 years) in 1999 (43% of fractures in 1999 versus 25% of fractures in 2019). Conversely, small children (1-5 years) had significantly more fractures in 2019 (36%) than in 1999 (24%). Conclusions: Overall, the types and sites of fractures did not change over the studied time despite a change in the population and mechanism of injury. This suggested that the reflexes of breaking a fall still tended to implicate and damage the same bone segments. Finally, the proportion of fractures managed surgically versus orthopedically has not evolved since 1999. Exploring this is a possible area of further research that would complement our study.

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