• Chemotherapy for resistant or recurrent gestational trophoblastic neoplasia.

      Alazzam, Mo'iad; Tidy, John; Osborne, Raymond; Coleman, Robert; Hancock, Barry W; Lawrie, Theresa A; Department of Gynaecology, The Galway Clinic, Doughiska, Galway, Ireland. moiad@doctors.org.uk (2012-12)
      Gestational trophoblastic neoplasia (GTN) is a highly curable group of pregnancy-related tumours; however, approximately 25% of GTN tumours will be resistant to, or will relapse after, initial chemotherapy. These resistant and relapsed lesions will require salvage chemotherapy with or without surgery. Various salvage regimens are used worldwide. It is unclear which regimens are the most effective and the least toxic.
    • First-line chemotherapy in low-risk gestational trophoblastic neoplasia.

      Alazzam, Mo'iad; Tidy, John; Hancock, Barry W; Osborne, Raymond; Lawrie, Theresa A; Department of Gynaecology, The Galway Clinic, Doughiska, Galway, Ireland. moiad@doctors.org.uk (2012)
      This is an update of a Cochrane review that was first published in Issue 1, 2009. Gestational trophoblastic neoplasia (GTN) is a rare but curable disease arising in the fetal chorion during pregnancy. Most women with low-risk GTN will be cured by evacuation of the uterus with or without single-agent chemotherapy. However, chemotherapy regimens vary between treatment centres worldwide and the comparable benefits and risks of these different regimens are unclear.