14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis.
Gu, Ting Ting
Carey, Mark S
Hennessy, Bryan T
Bishop, Alexander J R
AffiliationGreehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, Texas, United States of America.
Dose-Response Relationship, Drug
Gene Expression Regulation, Neoplastic
Tumor Cells, Cultured
MetadataShow full item record
Citation14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis. 2011, 6 (1):e15864 PLoS ONE
AbstractIn vitro cell culture experiments with primary cells have reported that cell proliferation is retarded in the presence of ambient compared to physiological O₂ levels. Cancer is primarily a disease of aberrant cell proliferation, therefore, studying cancer cells grown under ambient O₂ may be undesirable. To understand better the impact of O₂ on the propagation of cancer cells in vitro, we compared the growth potential of a panel of ovarian cancer cell lines under ambient (21%) or physiological (3%) O₂.