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    11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.

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    Authors
    Morgan, Stuart A
    Sherlock, Mark
    Gathercole, Laura L
    Lavery, Gareth G
    Lenaghan, Carol
    Bujalska, Iwona J
    Laber, David
    Yu, Alice
    Convey, Gemma
    Mayers, Rachel
    Hegyi, Krisztina
    Sethi, Jaswinder K
    Stewart, Paul M
    Smith, David M
    Tomlinson, Jeremy W
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    Affiliation
    Centre for Endocrinology, Diabetes and Metabolism, Institute of Biomedical Research, School of Clinical & Experimental Medicine, University of Birmingham, Birmingham, U.K.
    Issue Date
    2009-11
    MeSH
    11-beta-Hydroxysteroid Dehydrogenase Type 1
    Animals
    Cell Line
    Cells, Cultured
    Deoxyglucose
    Dexamethasone
    Glucocorticoids
    Humans
    Insulin
    Insulin Resistance
    Kinetics
    Mice
    Muscle, Skeletal
    Myoblasts
    Polymerase Chain Reaction
    RNA
    RNA, Messenger
    Reverse Transcriptase Polymerase Chain Reaction
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    Citation
    11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle. 2009, 58 (11):2506-15 Diabetes
    Publisher
    Diabetes
    Journal
    Diabetes
    URI
    http://hdl.handle.net/10147/254113
    DOI
    10.2337/db09-0525
    PubMed ID
    19675138
    Abstract
    Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown. Within skeletal muscle, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone (11-dehydrocorticosterone in rodents) to active cortisol (corticosterone in rodents). We aimed to determine the mechanisms underpinning glucocorticoid-induced insulin resistance in skeletal muscle and indentify how 11beta-HSD1 inhibitors improve insulin sensitivity.
    Item Type
    Article
    Language
    en
    ISSN
    1939-327X
    ae974a485f413a2113503eed53cd6c53
    10.2337/db09-0525
    Scopus Count
    Collections
    Tallaght University Hospital

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