11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.

Authors
Morgan, Stuart A
Sherlock, Mark
Gathercole, Laura L
Lavery, Gareth G
Lenaghan, Carol
Bujalska, Iwona J
Laber, David
Yu, Alice
Convey, Gemma
Mayers, Rachel
Affiliation
Centre for Endocrinology, Diabetes and Metabolism, Institute of Biomedical Research, School of Clinical & Experimental Medicine, University of Birmingham, Birmingham, U.K.
Issue Date
2009-11
MeSH
11-beta-Hydroxysteroid Dehydrogenase Type 1
Animals
Cell Line
Cells, Cultured
Deoxyglucose
Dexamethasone
Glucocorticoids
Humans
Insulin
Insulin Resistance

Metadata
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Citation
11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle. 2009, 58 (11):2506-15 Diabetes
Publisher
Diabetes
Journal
Diabetes
URI
http://hdl.handle.net/10147/254113
DOI
10.2337/db09-0525
PubMed ID
19675138
Abstract
Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown. Within skeletal muscle, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone (11-dehydrocorticosterone in rodents) to active cortisol (corticosterone in rodents). We aimed to determine the mechanisms underpinning glucocorticoid-induced insulin resistance in skeletal muscle and indentify how 11beta-HSD1 inhibitors improve insulin sensitivity.
Item Type
Article
Language
en
ISSN
1939-327X
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