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dc.contributor.authorRichiardi, Lorenzo
dc.contributor.authorCorbin, Marine
dc.contributor.authorMarron, Manuela
dc.contributor.authorAhrens, Wolfgang
dc.contributor.authorPohlabeln, Hermann
dc.contributor.authorLagiou, Pagona
dc.contributor.authorMinaki, Ploumitsa
dc.contributor.authorAgudo, Antonio
dc.contributor.authorCastellsague, Xavier
dc.contributor.authorSlamova, Alena
dc.contributor.authorSchejbalova, Miriam
dc.contributor.authorKjaerheim, Kristina
dc.contributor.authorBarzan, Luigi
dc.contributor.authorTalamini, Renato
dc.contributor.authorMacfarlane, Gary J
dc.contributor.authorMacfarlane, Tatiana V
dc.contributor.authorCanova, Cristina
dc.contributor.authorSimonato, Lorenzo
dc.contributor.authorConway, David I
dc.contributor.authorMcKinney, Patricia A
dc.contributor.authorSneddon, Linda
dc.contributor.authorThomson, Peter
dc.contributor.authorZnaor, Ariana
dc.contributor.authorHealy, Claire M
dc.contributor.authorMcCartan, Bernard E
dc.contributor.authorBenhamou, Simone
dc.contributor.authorBouchardy, Christine
dc.contributor.authorHashibe, Mia
dc.contributor.authorBrennan, Paul
dc.contributor.authorMerletti, Franco
dc.date.accessioned2013-05-14T11:28:46Z
dc.date.available2013-05-14T11:28:46Z
dc.date.issued2012-05-15
dc.identifier.citationOccupation and risk of upper aerodigestive tract cancer: the ARCAGE study. 2012, 130 (10):2397-406 Int. J. Canceren_GB
dc.identifier.issn1097-0215
dc.identifier.pmid21671472
dc.identifier.doi10.1002/ijc.26237
dc.identifier.urihttp://hdl.handle.net/10147/291060
dc.description.abstractWe investigated the association between occupational history and upper aerodigestive tract (UADT) cancer risk in the ARCAGE European case-control study. The study included 1,851 patients with incident cancer of the oral cavity, oropharynx, hypopharynx, larynx or esophagus and 1,949 controls. We estimated odds ratios (OR) and 95% confidence intervals (CI) for ever employment in 283 occupations and 172 industries, adjusting for smoking and alcohol. Men (1,457 cases) and women (394 cases) were analyzed separately and we incorporated a semi-Bayes adjustment approach for multiple comparisons. Among men, we found increased risks for occupational categories previously reported to be associated with at least one type of UADT cancer, including painters (OR = 1.74, 95% CI: 1.01-3.00), bricklayers (1.58, 1.05-2.37), workers employed in the erection of roofs and frames (2.62, 1.08-6.36), reinforced concreters (3.46, 1.11-10.8), dockers (2.91, 1.05-8.05) and workers employed in the construction of roads (3.03, 1.23-7.46), general construction of buildings (1.44, 1.12-1.85) and cargo handling (2.60, 1.17-5.75). With the exception of the first three categories, risks both increased when restricting to long duration of employment and remained elevated after semi-Bayes adjustment. Increased risks were also found for loggers (3.56, 1.20-10.5) and cattle and dairy farming (3.60, 1.15-11.2). Among women, there was no clear evidence of increased risks of UADT cancer in association with occupations or industrial activities. This study provides evidence of an association between some occupational categories and UADT cancer risk among men. The most consistent findings, also supported by previous studies, were obtained for specific workers employed in the construction industry.
dc.language.isoenen
dc.rightsArchived with thanks to International journal of cancer. Journal international du canceren_GB
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCase-Control Studies
dc.subject.meshConstruction Industry
dc.subject.meshEsophageal Neoplasms
dc.subject.meshEurope
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLaryngeal Neoplasms
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMouth Neoplasms
dc.subject.meshNeoplasms
dc.subject.meshOccupations
dc.subject.meshPharyngeal Neoplasms
dc.subject.meshRisk
dc.subject.meshRisk Factors
dc.titleOccupation and risk of upper aerodigestive tract cancer: the ARCAGE study.en_GB
dc.typeArticleen
dc.contributor.departmentUniversity of Turin, Turin, Italy. lorenzo.richiardi@unito.iten_GB
dc.identifier.journalInternational journal of cancer. Journal international du canceren_GB
dc.description.provinceLeinsteren
html.description.abstractWe investigated the association between occupational history and upper aerodigestive tract (UADT) cancer risk in the ARCAGE European case-control study. The study included 1,851 patients with incident cancer of the oral cavity, oropharynx, hypopharynx, larynx or esophagus and 1,949 controls. We estimated odds ratios (OR) and 95% confidence intervals (CI) for ever employment in 283 occupations and 172 industries, adjusting for smoking and alcohol. Men (1,457 cases) and women (394 cases) were analyzed separately and we incorporated a semi-Bayes adjustment approach for multiple comparisons. Among men, we found increased risks for occupational categories previously reported to be associated with at least one type of UADT cancer, including painters (OR = 1.74, 95% CI: 1.01-3.00), bricklayers (1.58, 1.05-2.37), workers employed in the erection of roofs and frames (2.62, 1.08-6.36), reinforced concreters (3.46, 1.11-10.8), dockers (2.91, 1.05-8.05) and workers employed in the construction of roads (3.03, 1.23-7.46), general construction of buildings (1.44, 1.12-1.85) and cargo handling (2.60, 1.17-5.75). With the exception of the first three categories, risks both increased when restricting to long duration of employment and remained elevated after semi-Bayes adjustment. Increased risks were also found for loggers (3.56, 1.20-10.5) and cattle and dairy farming (3.60, 1.15-11.2). Among women, there was no clear evidence of increased risks of UADT cancer in association with occupations or industrial activities. This study provides evidence of an association between some occupational categories and UADT cancer risk among men. The most consistent findings, also supported by previous studies, were obtained for specific workers employed in the construction industry.


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