Cardiovascular disease: primary prevention, disease modulation and regenerative therapy.
AffiliationDepartment of Vascular and Endovascular Surgery, Western Vascular Institute, University College Hospital Galway, Ireland. email@example.com
Recovery of Function
MetadataShow full item record
CitationCardiovascular disease: primary prevention, disease modulation and regenerative therapy. 2012, 20 (5):243-50 Vascular
AbstractCardiovascular primary prevention and regeneration programs are the contemporary frontiers in functional metabolic vascular medicine. This novel science perspective harnesses our inherent ability to modulate the interface between specialized gene receptors and bioavailable nutrients in what is labeled as the nutrient-gene interaction. By mimicking a natural process through the conveyance of highly absorbable receptor specific nutrients, it is feasible to accelerate cell repair and optimize mitochondrial function, thereby achieving cardiovascular cure. We performed a comprehensive review of PubMed, EMBASE and Cochrane Review databases for articles relating to cardiovascular regenerative medicine, nutrigenomics and primary prevention, with the aim of harmonizing their roles within contemporary clinical practice. We searched in particular for large-scale randomized controlled trials on contemporary cardiovascular pharmacotherapies and their specific adverse effects on metabolic pathways which feature prominently in cardiovascular regenerative programs, such as nitric oxide and glucose metabolism. Scientific research on 'cardiovascular-free' centenarians delineated that low sugar and low insulin are consistent findings. As we age, our insulin level increases. Those who can decelerate the rapidity of this process are prompting their cardiovascular rejuvenation. It is beginning to dawn on some clinicians that contemporary treatments are not only failing to impact on our most prevalent diseases, but they may be causing more damage than good. Primary prevention programs are crucial elements for a better outcome. Cardiovascular primary prevention and regeneration programs have enhanced clinical efficacy and quality of life and complement our conventional endovascular practice.
- Stem cell therapy in cardiovascular disorders.
- Authors: Krause K, Schneider C, Kuck KH, Jaquet K
- Issue date: 2010 Oct
- Regenerative medicine for cardiovascular disorders-new milestones: adult stem cells.
- Authors: Akar AR, Durdu S, Corapcioglu T, Ozyurda U
- Issue date: 2006 Apr
- Quest for the cardiovascular holy grail: mammalian myocardial regeneration.
- Authors: Vela D, Buja LM
- Issue date: 2008 Jan-Feb
- Tissue Engineering-Bridging the Gap.
- Authors: Chester AH
- Issue date: 2017 Apr
- Representation of women in randomized clinical trials of cardiovascular disease prevention.
- Authors: Melloni C, Berger JS, Wang TY, Gunes F, Stebbins A, Pieper KS, Dolor RJ, Douglas PS, Mark DB, Newby LK
- Issue date: 2010 Mar