An experimental investigation of the hemodynamic variations due to aplastic vessels within three-dimensional phantom models of the Circle of Willis.
AffiliationGalway Medical Technologies Centre (GMedTech), Department of Mechanical and Industrial Engineering, Galway Mayo Institute of Technology, Galway, Ireland.
MetadataShow full item record
CitationAn Experimental Investigation of the Hemodynamic Variations Due to Aplastic Vessels Within Three-Dimensional Phantom Models of the Circle of Willis. 2013: Ann Biomed Eng
PublisherAnnals of biomedical engineering
JournalAnnals of biomedical engineering
AbstractA complete circle of Willis (CoW) is found in approximately 30-50% of the population. Anatomical variations, such as absent or surgically clamped vessels, can result in undesirable flow patterns. These can affect the brain's ability to maintain cerebral perfusion and the formation of cerebral aneurysms. An experimental test system was developed to simulate cerebral physiological conditions through three flexible 3D patient-specific models of complete and incomplete CoW geometries. Flow visualizations were performed with isobaric dyes and the mapped dye streamlines were tracked throughout the models. Three to seven flow impact locations were observed for all configurations, corresponding to known sites for aneurysmal formation. Uni and bi-directional cross-flows occurred along the communicating arteries. The greatest shunting of flow occurred for a missing pre-communicating anterior (A1) and posterior (P1) cerebral arteries. The anterior cerebral arteries had the greatest reduction (15-37%) in efferent flow rates for missing either a unilateral A1 or bilateral P1 segments. The bi-directional cross-flows, with multiple afferent flow mixing, observed along the communicating arteries may explain the propensity of aneurysm formation at these sites. Reductions in efferent flow rates due to aplastic vessel configurations may affect normal brain function.
- An in vitro assessment of the cerebral hemodynamics through three patient specific circle of Willis geometries.
- Authors: Fahy P, Delassus P, McCarthy P, Sultan S, Hynes N, Morris L
- Issue date: 2014 Jan
- Cross-flow at the anterior communicating artery and its implication in cerebral aneurysm formation.
- Authors: Jou LD, Lee DH, Mawad ME
- Issue date: 2010 Aug 10
- Aneurysmal Parent Artery-Specific Inflow Conditions for Complete and Incomplete Circle of Willis Configurations.
- Authors: Cornelissen BMW, Schneiders JJ, Sprengers ME, van den Berg R, van Ooij P, Nederveen AJ, van Bavel E, Vandertop WP, Slump CH, Marquering HA, Majoie CBLM
- Issue date: 2018 May
- [Relationship between the afferent artery and the site of neck of anterior communicating artery aneurysm, and hemodynamics in the anterior part of the circle of Willis (author's transl)].
- Authors: Kwak R, Ohi T, Niizuma H, Suzuki J
- Issue date: 1978 Dec
- Modelling the circle of Willis to assess the effects of anatomical variations and occlusions on cerebral flows.
- Authors: Alastruey J, Parker KH, Peiró J, Byrd SM, Sherwin SJ
- Issue date: 2007