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dc.contributor.authorCoyle, D
dc.contributor.authorQuinlan, MR
dc.contributor.authorD’Arcy, FT
dc.contributor.authorKelly, BD
dc.contributor.authorCorcoran, O
dc.contributor.authorDurkan, GC
dc.contributor.authorJaffry, S
dc.contributor.authorWalsh, K
dc.contributor.authorRogers, E
dc.date.accessioned2015-09-18T15:30:28Zen
dc.date.available2015-09-18T15:30:28Zen
dc.date.issued2015-09en
dc.identifier.urihttp://hdl.handle.net/10147/578171en
dc.description.abstractRadical nephrectomy (RN) is an independent risk factor for the development of chronic kidney disease (CKD) in those with renal cell carcinoma (RCC). We aimed to examine the pattern of change in post-operative renal function in patients who underwent RN for RCC over a 3 year period at our institution. We performed a retrospective review of histological and biochemical findings in patients undergoing RN for RCC over a 38 month period. Estimated glomerular filtration rate (eGFR) was recorded pre- and post-operatively and at follow-up. We analysed data on 131 patients (median follow-up 24 months). The proportion of patients with advanced CKD increased significantly at follow-up with 48 (85.7%) patients, classified as having stage 2 CKD pre-operatively, being re-classified as stage 3-5. Mean eGFR was significantly lower pre-operatively (76.6 mL/min/1.73 m2) compared to hospital discharge (61 mL/ min/1.73 m2, p<0.001) and follow-up (55.5 mL/min/1.73 m2, p<0.001). Those with pT1 tumours sustained a significantly greater decline in eGFR compared to other stages. In conclusion, patients with pT1a and pT1b tumours sustain a disproportionate decline in renal function and may benefit the most from NSS.
dc.language.isoenen
dc.subjectKIDNEY DISEASEen
dc.subjectCANCERen
dc.titlePattern of change in renal function following radical nephrectomy for renal cell carcinomaen
dc.typeArticleen
dc.identifier.journalIrish Medical Journalen
dc.description.fundingNo fundingen
dc.description.provinceConnachten
dc.description.peer-reviewpeer-reviewen
refterms.dateFOA2018-08-27T09:21:56Z
html.description.abstractRadical nephrectomy (RN) is an independent risk factor for the development of chronic kidney disease (CKD) in those with renal cell carcinoma (RCC). We aimed to examine the pattern of change in post-operative renal function in patients who underwent RN for RCC over a 3 year period at our institution. We performed a retrospective review of histological and biochemical findings in patients undergoing RN for RCC over a 38 month period. Estimated glomerular filtration rate (eGFR) was recorded pre- and post-operatively and at follow-up. We analysed data on 131 patients (median follow-up 24 months). The proportion of patients with advanced CKD increased significantly at follow-up with 48 (85.7%) patients, classified as having stage 2 CKD pre-operatively, being re-classified as stage 3-5. Mean eGFR was significantly lower pre-operatively (76.6 mL/min/1.73 m2) compared to hospital discharge (61 mL/ min/1.73 m2, p<0.001) and follow-up (55.5 mL/min/1.73 m2, p<0.001). Those with pT1 tumours sustained a significantly greater decline in eGFR compared to other stages. In conclusion, patients with pT1a and pT1b tumours sustain a disproportionate decline in renal function and may benefit the most from NSS.


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