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    Standardized Parenteral Nutrition for the Transition Phase in Preterm Infants: A Bag That Fits.

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    Authors
    Brennan, Ann-Marie
    Kiely, Mairead E
    Fenton, Sarah
    Murphy, Brendan P
    Issue Date
    2018-02-02
    Keywords
    NUTRITION
    Premature Infant
    
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    Citation
    Standardized Parenteral Nutrition for the Transition Phase in Preterm Infants: A Bag That Fits. 2018, 10 (2) Nutrients
    Publisher
    Nutrients
    Journal
    Nutrients
    URI
    http://hdl.handle.net/10147/622834
    DOI
    10.3390/nu10020170
    PubMed ID
    29393903
    Abstract
    The optimal composition of standardized parenteral nutrition (SPN) is not yet known, contributing to nutrient deficit accrual and growth failure, with the period of parenteral nutrition weaning, i.e., transition (TN) phase, being identified as particularly vulnerable. We created a comprehensive nutrition database, representative of the nutritional course of a diverse range of preterm infants (n = 59, birth weight ≤ 1500 g, gestation < 34 weeks) by collecting hourly macronutrient intake data as part of a prospective, observational study over 19 months. Using a nutrient modeling technique for the TN phase, various amino acid (AA) concentrations of SPN were tested within the database, whilst acknowledging the nutritional contribution from enteral feeds until target AA intakes were consistently achieved. From the modeling, the AA composition of SPN was determined at 3.5 g/100 mL, which was the maximum to avoid exceeding target intakes at any point in the TN phase. However, in order to consistently achieve target AA intakes, additional nutritional strategies were required, which included increasing the exclusion of enteral feeds in fluid and nutrient calculations from <20 mL/kg/day to <40 mL/kg/day, and earlier fortification of breastmilk at 80 mL/kg/day. This data-driven nutrient modeling process supported the development of an improved SPN regimen for our preterm population in the TN phase.
    Item Type
    Article
    Language
    en
    ISSN
    2072-6643
    ae974a485f413a2113503eed53cd6c53
    10.3390/nu10020170
    Scopus Count
    Collections
    Cork University Maternity Hospital

    entitlement

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