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dc.contributor.authorKumar A U, Arun
dc.contributor.authorBrowne, Leonard D
dc.contributor.authorLi, Xia
dc.contributor.authorAdeeb, Fahd
dc.contributor.authorPerez-Ruiz, Fernando
dc.contributor.authorFraser, Alexander D
dc.contributor.authorStack, Austin G
dc.date.accessioned2018-06-12T09:09:39Z
dc.date.available2018-06-12T09:09:39Z
dc.date.issued2018-05
dc.identifier.citationTemporal trends in hyperuricaemia in the Irish health system from 2006-2014: A cohort study. 2018, 13 (5):e0198197 PLoS ONEen
dc.identifier.issn1932-6203
dc.identifier.pmid29852506
dc.identifier.doi10.1371/journal.pone.0198197
dc.identifier.urihttp://hdl.handle.net/10147/623048
dc.descriptionElevated serum uric acid (sUA) concentrations are common in the general population and are associated with chronic metabolic conditions and adverse clinical outcomes. We evaluated secular trends in the burden of hyperuricaemia from 2006-2014 within the Irish health system.en
dc.description.abstractElevated serum uric acid (sUA) concentrations are common in the general population and are associated with chronic metabolic conditions and adverse clinical outcomes. We evaluated secular trends in the burden of hyperuricaemia from 2006-2014 within the Irish health system.
dc.description.abstractData from the National Kidney Disease Surveillance Programme was used to determine the prevalence of elevated sUA in adults, age > 18 years, within the Irish health system. Hyperuricaemia was defined as sUA > 416.4 μmol/L in men and > 339.06 μmol/L in women, and prevalence was calculated as the proportion of patients per year with mean sUA levels above sex-specific thresholds. Temporal trends in prevalence were compared from 2006 to 2014 while general estimating equations (GEE) explored variation across calendar years expressed as odds ratios (OR) and 95% Confidence intervals (CI).
dc.description.abstractFrom 2006 to 2014, prevalence of hyperuricaemia increased from 19.7% to 25.0% in men and from 20.5% to 24.1% in women, P<0.001. The corresponding sUA concentrations increased significantly from 314.6 (93.9) in 2006 to 325.6 (96.2) in 2014, P<0.001. Age-specific prevalence increased in all groups from 2006 to 2014, and the magnitude of increase was similar for each age category. Adjusting for baseline demographic characteristics and illness indicators, the likelihood of hyperuricemia was greatest for patients in 2014; OR 1.45 (1.26-1.65) for men and OR 1.47 (1.29-1.67) in women vs 2006 (referent). Factors associated with hyperuricaemia included: worsening kidney function, elevated white cell count, raised serum phosphate and calcium levels, elevated total protein and higher haemoglobin concentrations, all P<0.001.
dc.description.abstractThe burden of hyperuricaemia is substantial in the Irish health system and has increased in frequency over the past decade. Advancing age, poorer kidney function, measures of nutrition and inflammation, and regional variation all contribute to increasing prevalence, but these do not fully explain emerging trends.
dc.language.isoenen
dc.publisherPLoS ONEen
dc.relation.urlhttp://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198197&type=printableen
dc.rightsArchived with thanks to PloS oneen
dc.subjectMETABOLIC DISORDERSen
dc.subject.otherURIC ACIDen
dc.titleTemporal trends in hyperuricaemia in the Irish health system from 2006-2014: A cohort study.en
dc.typeArticleen
dc.identifier.journalPloS oneen
refterms.dateFOA2018-08-28T03:29:01Z
html.description.abstractElevated serum uric acid (sUA) concentrations are common in the general population and are associated with chronic metabolic conditions and adverse clinical outcomes. We evaluated secular trends in the burden of hyperuricaemia from 2006-2014 within the Irish health system.
html.description.abstractData from the National Kidney Disease Surveillance Programme was used to determine the prevalence of elevated sUA in adults, age > 18 years, within the Irish health system. Hyperuricaemia was defined as sUA > 416.4 μmol/L in men and > 339.06 μmol/L in women, and prevalence was calculated as the proportion of patients per year with mean sUA levels above sex-specific thresholds. Temporal trends in prevalence were compared from 2006 to 2014 while general estimating equations (GEE) explored variation across calendar years expressed as odds ratios (OR) and 95% Confidence intervals (CI).
html.description.abstractFrom 2006 to 2014, prevalence of hyperuricaemia increased from 19.7% to 25.0% in men and from 20.5% to 24.1% in women, P<0.001. The corresponding sUA concentrations increased significantly from 314.6 (93.9) in 2006 to 325.6 (96.2) in 2014, P<0.001. Age-specific prevalence increased in all groups from 2006 to 2014, and the magnitude of increase was similar for each age category. Adjusting for baseline demographic characteristics and illness indicators, the likelihood of hyperuricemia was greatest for patients in 2014; OR 1.45 (1.26-1.65) for men and OR 1.47 (1.29-1.67) in women vs 2006 (referent). Factors associated with hyperuricaemia included: worsening kidney function, elevated white cell count, raised serum phosphate and calcium levels, elevated total protein and higher haemoglobin concentrations, all P<0.001.
html.description.abstractThe burden of hyperuricaemia is substantial in the Irish health system and has increased in frequency over the past decade. Advancing age, poorer kidney function, measures of nutrition and inflammation, and regional variation all contribute to increasing prevalence, but these do not fully explain emerging trends.


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