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dc.contributor.authorBartels, Helena C
dc.contributor.authorPostle, James D
dc.contributor.authorDowney, Paul
dc.contributor.authorBrennan, Donal J
dc.date.accessioned2018-12-17T16:57:46Z
dc.date.available2018-12-17T16:57:46Z
dc.date.issued2018-01-01
dc.identifier.citationHelena C. Bartels, James D. Postle, Paul Downey, and Donal J. Brennan, “Placenta Accreta Spectrum: A Review of Pathology, Molecular Biology, and Biomarkers,” Disease Markers, vol. 2018, Article ID 1507674, 11 pages, 2018. https://doi.org/10.1155/2018/1507674.en_US
dc.identifier.issn1875-8630
dc.identifier.pmid30057649
dc.identifier.pmid30057649
dc.identifier.doi10.1155/2018/1507674
dc.identifier.urihttp://hdl.handle.net/10147/623961
dc.description.abstractPlacenta accreta spectrum (PAS) is a condition of abnormal placental invasion encompassing placenta accreta, increta, and percreta and is a major cause of severe maternal morbidity and mortality. The diagnosis of a PAS is made on the basis of histopathologic examination and characterised by an absence of decidua and chorionic villi are seen to directly adjacent to myometrial fibres. The underlying molecular biology of PAS is a complex process that requires further research; for ease, we have divided these processes into angiogenesis, proliferation, and inflammation/invasion. A number of diagnostic serum biomarkers have been investigated in PAS, including human chorionic gonadotropin (HCG), pregnancy-associated plasma protein-A (PAPP-A), and alpha-fetoprotein (AFP). They have shown variable reliability and variability of measurement depending on gestational age at sampling. At present, a sensitive serum biomarker for invasive placentation remains elusive. In summary, there are a limited number of studies that have contributed to our understanding of the molecular biology of PAS, and additional biomarkers are needed to aid diagnosis and disease stratification.en_US
dc.language.isoenen_US
dc.publisherHindawien_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectPREGNANCYen_US
dc.subject.otherBIOMARKERSen_US
dc.titlePlacenta Accreta Spectrum: A Review of Pathology, Molecular Biology, and Biomarkers.en_US
dc.typeArticleen_US
dc.contributor.department1 National Maternity Hospital, Holles Street, Dublin 2, Ireland. 2 UCD School of Medicine, National Maternity Hospital, Holles Street, Dublin 2, Irelanden_US
dc.identifier.journalDisease Markersen_US
dc.description.fundingNo fundingen_US
dc.description.provinceLeinsteren_US
dc.description.peer-reviewpeer-reviewen_US
dc.source.journaltitleDisease markers
refterms.dateFOA2018-12-17T16:57:46Z


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