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dc.contributor.authorFouhy, Fiona
dc.contributor.authorWatkins, Claire
dc.contributor.authorHill, Cian J
dc.contributor.authorO'Shea, Carol-Anne
dc.contributor.authorNagle, Brid
dc.contributor.authorDempsey, Eugene M
dc.contributor.authorO'Toole, Paul W
dc.contributor.authorRoss, R Paul
dc.contributor.authorRyan, C Anthony
dc.contributor.authorStanton, Catherine
dc.date.accessioned2020-03-04T10:01:48Z
dc.date.available2020-03-04T10:01:48Z
dc.date.issued2019-04-03
dc.identifier.pmid30944304
dc.identifier.doi10.1038/s41467-019-09252-4
dc.identifier.urihttp://hdl.handle.net/10147/627257
dc.description.abstractPerinatal factors impact gut microbiota development in early life, however, little is known on the effects of these factors on microbes in later life. Here we sequence DNA from faecal samples of children over the first four years and reveal a perpetual evolution of the gut microbiota during this period. The significant impact of gestational age at birth and delivery mode on gut microbiota progression is evident in the first four years of life, while no measurable effects of antibiotics are found in the first year. Microbiota profiles are also characteristic in children dependant on gestational age and maturity. Full term delivery is characterised by Bacteroides (year one), Parabacteroides (year two) and Christensenellaceae (year four). Preterm delivery is characterised by Lactobacillus (year one), Streptococcus (year two) and Carnobacterium (year four). This study reveals that the gut retains distinct microbial profiles of perinatal factors up to four years of age.en_US
dc.language.isoenen_US
dc.subjectCHILDBIRTHen_US
dc.subjectGUT MICROBIOMEen_US
dc.subjectINFANTSen_US
dc.titlePerinatal factors affect the gut microbiota up to four years after birth.en_US
dc.typeArticleen_US
dc.identifier.eissn2041-1723
dc.identifier.journalNature communicationsen_US
dc.description.peer-reviewpeer-reviewen_US
dc.source.journaltitleNature communications
dc.source.volume10
dc.source.issue1
dc.source.beginpage1517
dc.source.endpage
refterms.dateFOA2020-03-04T10:01:48Z
dc.source.countryEngland


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