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dc.contributor.authorGarcía-Gutiérrez, Lucía
dc.contributor.authorDelgado, María Dolores
dc.contributor.authorLeón, Javier
dc.date.accessioned2020-03-05T13:14:18Z
dc.date.available2020-03-05T13:14:18Z
dc.date.issued2019-03-22
dc.identifier.issn2073-4425
dc.identifier.pmid30909496
dc.identifier.doi10.3390/genes10030244
dc.identifier.urihttp://hdl.handle.net/10147/627270
dc.descriptionPromotion of the cell cycle is a major oncogenic mechanism of the oncogene c-MYC (MYC). MYC promotes the cell cycle by not only activating or inducing cyclins and CDKs but also through the downregulation or the impairment of the activity of a set of proteins that act as cell-cycle brakes. This review is focused on the role of MYC as a cell-cycle brake releaser i.e., how MYC stimulates the cell cycle mainly through the functional inactivation of cell cycle inhibitors. MYC antagonizes the activities and/or the expression levels of p15, ARF, p21, and p27. The mechanism involved differs for each protein. p15 (encoded by CDKN2B) and p21 (CDKN1A) are repressed by MYC at the transcriptional level. In contrast, MYC activates ARF, which contributes to the apoptosis induced by high MYC levels. At least in some cells types, MYC inhibits the transcription of the p27 gene (CDKN1B) but also enhances p27's degradation through the upregulation of components of ubiquitin ligases complexes. The effect of MYC on cell-cycle brakes also opens the possibility of antitumoral therapies based on synthetic lethal interactions involving MYC and CDKs, for which a series of inhibitors are being developed and tested in clinical trials.en_US
dc.language.isoenen_US
dc.subjectARFen_US
dc.subjectCDK inhibitorsen_US
dc.subjectMYCen_US
dc.subjectcell cycleen_US
dc.subjectp15en_US
dc.subjectp21en_US
dc.subjectp27en_US
dc.titleMYC Oncogene Contributions to Release of Cell Cycle Brakes.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.journalGenesen_US
dc.source.journaltitleGenes
dc.source.volume10
dc.source.issue3
refterms.dateFOA2020-03-05T13:14:18Z
dc.source.countrySwitzerland


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