Systematic review and network meta-analysis with individual participant data on cord management at preterm birth (iCOMP): study protocol.
Authors
Seidler, Anna LeneDuley, Lelia
Katheria, Anup C
De Paco Matallana, Catalina
Dempsey, Eugene
Rabe, Heike
Kattwinkel, John
Mercer, Judith
Josephsen, Justin
Fairchild, Karen
Andersson, Ola
Hosono, Shigeharu
Sundaram, Venkataseshan
Datta, Vikram
El-Naggar, Walid
Tarnow-Mordi, William
Debray, Thomas
Hooper, Stuart B
Kluckow, Martin
Polglase, Graeme
Davis, Peter G
Montgomery, Alan
Hunter, Kylie E
Barba, Angie
Simes, John
Askie, Lisa
Issue Date
2020-03-29Keywords
individual participant data meta-analysisnetwork meta-analysis
placental transfusion
preterm birth
prospective meta-analysis
umbilical cord clamping
umbilical cord milking
Metadata
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BMJ openDOI
10.1136/bmjopen-2019-034595PubMed ID
32229522Abstract
ntroduction: Timing of cord clamping and other cord management strategies may improve outcomes at preterm birth. However, it is unclear whether benefits apply to all preterm subgroups. Previous and current trials compare various policies, including time-based or physiology-based deferred cord clamping, and cord milking. Individual participant data (IPD) enable exploration of different strategies within subgroups. Network meta-analysis (NMA) enables comparison and ranking of all available interventions using a combination of direct and indirect comparisons. Objectives: (1) To evaluate the effectiveness of cord management strategies for preterm infants on neonatal mortality and morbidity overall and for different participant characteristics using IPD meta-analysis. (2) To evaluate and rank the effect of different cord management strategies for preterm births on mortality and other key outcomes using NMA. Methods and analysis: Systematic searches of Medline, Embase, clinical trial registries, and other sources for all ongoing and completed randomised controlled trials comparing cord management strategies at preterm birth (before 37 weeks' gestation) have been completed up to 13 February 2019, but will be updated regularly to include additional trials. IPD will be sought for all trials; aggregate summary data will be included where IPD are unavailable. First, deferred clamping and cord milking will be compared with immediate clamping in pairwise IPD meta-analyses. The primary outcome will be death prior to hospital discharge. Effect differences will be explored for prespecified participant subgroups. Second, all identified cord management strategies will be compared and ranked in an IPD NMA for the primary outcome and the key secondary outcomes. Treatment effect differences by participant characteristics will be identified. Inconsistency and heterogeneity will be explored.Item Type
ArticleOther
Language
enEISSN
2044-6055ae974a485f413a2113503eed53cd6c53
10.1136/bmjopen-2019-034595
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