Prevalence and clinical implications of respiratory viruses in stable chronic obstructive pulmonary disease (COPD) and exacerbations: a systematic review and meta-analysis protocol.
Authors
Kefala, Anastasia MFortescue, Rebecca
Alimani, Gioulinta S
Kanavidis, Prodromos
McDonnell, Melissa Jane
Magiorkinis, Emmanouil
Megremis, Spyridon
Paraskevis, Dimitrios
Voyiatzaki, Chrysa
Mathioudakis, Georgios A
Papageorgiou, Effie
Papadopoulos, Nikolaos G
Vestbo, Jørgen
Beloukas, Apostolos
Mathioudakis, Alexander G
Issue Date
2020-04-07Keywords
adult thoracic medicinechronic airways disease
epidemiology
RESPIRATORY INFECTIONS
Metadata
Show full item recordJournal
BMJ openDOI
10.1136/bmjopen-2019-035640PubMed ID
32269027Abstract
Introduction: Both stable chronic obstructive pulmonary disease (COPD) and acute exacerbations represent leading causes of death, disability and healthcare expenditure. They are complex, heterogeneous and their mechanisms are poorly understood. The role of respiratory viruses has been studied extensively but is still not adequately addressed clinically. Through a rigorous evidence update, we aim to define the prevalence and clinical burden of the different respiratory viruses in stable COPD and exacerbations, and to investigate whether viral load of usual respiratory viruses could be used for diagnosis of exacerbations triggered by viruses, which are currently not diagnosed or treated aetiologically. Methods and analysis: Based on a prospectively registered protocol, we will systematically review the literature using standard methods recommended by the Cochrane Collaboration and the Grading of Recommendations Assessment, Development and Evaluation working group. We will search Medline/PubMed, Excerpta Medica dataBASE (EMBASE), the Cochrane Library, the WHO's Clinical Trials Registry and the proceedings of relevant international conferences on 2 March 2020. We will evaluate: (A) the prevalence of respiratory viruses in stable COPD and exacerbations, (B) differences in the viral loads of respiratory viruses in stable COPD vs exacerbations, to explore whether the viral load of prevalent respiratory viruses could be used as a diagnostic biomarker for exacerbations triggered by viruses and (C) the association between the presence of respiratory viruses and clinical outcomes in stable COPD and in exacerbations. Ethics and dissemination: Ethics approval is not required since no primary data will be collected. Our findings will be presented in national and international scientific conferences and will be published in peer reviewed journals. Respiratory viruses currently represent a lost opportunity to improve the outcomes of both stable COPD and exacerbations. Our work aspires to 'demystify' the prevalence and clinical burden of viruses in stable COPD and exacerbations and to promote clinical and translational research.Item Type
ArticleOther
Language
enEISSN
2044-6055ae974a485f413a2113503eed53cd6c53
10.1136/bmjopen-2019-035640
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