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    Prevalence and clinical implications of respiratory viruses in stable chronic obstructive pulmonary disease (COPD) and exacerbations: a systematic review and meta-analysis protocol.

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    Authors
    Kefala, Anastasia M
    Fortescue, Rebecca
    Alimani, Gioulinta S
    Kanavidis, Prodromos
    McDonnell, Melissa Jane
    Magiorkinis, Emmanouil
    Megremis, Spyridon
    Paraskevis, Dimitrios
    Voyiatzaki, Chrysa
    Mathioudakis, Georgios A
    Papageorgiou, Effie
    Papadopoulos, Nikolaos G
    Vestbo, Jørgen
    Beloukas, Apostolos
    Mathioudakis, Alexander G
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    Issue Date
    2020-04-07
    Keywords
    adult thoracic medicine
    chronic airways disease
    epidemiology
    RESPIRATORY INFECTIONS
    
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    Show full item record
    Journal
    BMJ open
    URI
    http://hdl.handle.net/10147/629556
    DOI
    10.1136/bmjopen-2019-035640
    PubMed ID
    32269027
    Abstract
    Introduction: Both stable chronic obstructive pulmonary disease (COPD) and acute exacerbations represent leading causes of death, disability and healthcare expenditure. They are complex, heterogeneous and their mechanisms are poorly understood. The role of respiratory viruses has been studied extensively but is still not adequately addressed clinically. Through a rigorous evidence update, we aim to define the prevalence and clinical burden of the different respiratory viruses in stable COPD and exacerbations, and to investigate whether viral load of usual respiratory viruses could be used for diagnosis of exacerbations triggered by viruses, which are currently not diagnosed or treated aetiologically. Methods and analysis: Based on a prospectively registered protocol, we will systematically review the literature using standard methods recommended by the Cochrane Collaboration and the Grading of Recommendations Assessment, Development and Evaluation working group. We will search Medline/PubMed, Excerpta Medica dataBASE (EMBASE), the Cochrane Library, the WHO's Clinical Trials Registry and the proceedings of relevant international conferences on 2 March 2020. We will evaluate: (A) the prevalence of respiratory viruses in stable COPD and exacerbations, (B) differences in the viral loads of respiratory viruses in stable COPD vs exacerbations, to explore whether the viral load of prevalent respiratory viruses could be used as a diagnostic biomarker for exacerbations triggered by viruses and (C) the association between the presence of respiratory viruses and clinical outcomes in stable COPD and in exacerbations. Ethics and dissemination: Ethics approval is not required since no primary data will be collected. Our findings will be presented in national and international scientific conferences and will be published in peer reviewed journals. Respiratory viruses currently represent a lost opportunity to improve the outcomes of both stable COPD and exacerbations. Our work aspires to 'demystify' the prevalence and clinical burden of viruses in stable COPD and exacerbations and to promote clinical and translational research.
    Item Type
    Article
    Other
    Language
    en
    EISSN
    2044-6055
    ae974a485f413a2113503eed53cd6c53
    10.1136/bmjopen-2019-035640
    Scopus Count
    Collections
    Galway University Hospitals

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