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Perinatal derivatives: How to best characterize their multimodal functions . Part C: Inflammation, angiogenesis, and wound healing.

dc.contributor.authorFlores, Ana I
dc.contributor.authorPipino, Caterina
dc.contributor.authorJerman, Urška Dragin
dc.contributor.authorLiarte, Sergio
dc.contributor.authorGindraux, Florelle
dc.contributor.authorKreft, Mateja Erdani
dc.contributor.authorNicolas, Francisco J
dc.contributor.authorPandolfi, Assunta
dc.contributor.authorTratnjek, Larisa
dc.contributor.authorGiebel, Bernd
dc.contributor.authorPozzobon, Michela
dc.contributor.authorSilini, Antonietta R
dc.contributor.authorParolini, Ornella
dc.contributor.authorEissner, Günther
dc.contributor.authorLang-Olip, Ingrid
dc.date.accessioned2024-06-04T09:40:45Z
dc.date.available2024-06-04T09:40:45Z
dc.date.issued2022-08-04
dc.identifier.issn2296-4185
dc.identifier.pmid35992360
dc.identifier.doi10.3389/fbioe.2022.965006
dc.identifier.urihttp://hdl.handle.net/10147/641733
dc.descriptionPerinatal derivatives (PnD) are birth-associated tissues, such as placenta, umbilical cord, amniotic and chorionic membrane, and thereof-derived cells as well as secretomes. PnD play an increasing therapeutic role with beneficial effects on the treatment of various diseases. The aim of this review is to elucidate the modes of action of non-hematopoietic PnD on inflammation, angiogenesis and wound healing. We describe the source and type of PnD with a special focus on their effects on inflammation and immune response, on vascular function as well as on cutaneous and oral wound healing, which is a complex process that comprises hemostasis, inflammation, proliferation (including epithelialization, angiogenesis), and remodeling. We further evaluate the different in vitro assays currently used for assessing selected functional and therapeutic PnD properties. This review is a joint effort from the COST SPRINT Action (CA17116) with the intention to promote PnD into the clinics. It is part of a quadrinomial series on functional assays for validation of PnD, spanning biological functions, such as immunomodulation, anti-microbial/anti-cancer activities, anti-inflammation, wound healing, angiogenesis, and regeneration.en_US
dc.language.isoenen_US
dc.rightsCopyright © 2022 Flores, Pipino, Jerman, Liarte, Gindraux, Kreft, Nicolas, Pandolfi, Tratnjek, Giebel, Pozzobon, Silini, Parolini, Eissner and Lang-Olip.
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectamniotic epithelial cellsen_US
dc.subjectamniotic membraneen_US
dc.subjectANGIOGENESISen_US
dc.subjectfunctional assaysen_US
dc.subjectinflammationen_US
dc.subjectmesenchymal stromal cellsen_US
dc.subjectperinatal derivativesen_US
dc.subjectwound healingen_US
dc.titlePerinatal derivatives: How to best characterize their multimodal functions . Part C: Inflammation, angiogenesis, and wound healing.en_US
dc.typeArticleen_US
dc.identifier.journalFrontiers in bioengineering and biotechnologyen_US
dc.source.journaltitleFrontiers in bioengineering and biotechnology
dc.source.volume10
dc.source.beginpage965006
dc.source.endpage
refterms.dateFOA2024-06-04T09:40:46Z
dc.source.countrySwitzerland


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Copyright © 2022 Flores, Pipino, Jerman, Liarte, Gindraux, Kreft, Nicolas, Pandolfi, Tratnjek, Giebel, Pozzobon, Silini, Parolini, Eissner and Lang-Olip.
Except where otherwise noted, this item's license is described as Copyright © 2022 Flores, Pipino, Jerman, Liarte, Gindraux, Kreft, Nicolas, Pandolfi, Tratnjek, Giebel, Pozzobon, Silini, Parolini, Eissner and Lang-Olip.