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dc.contributor.authorLaake, Jon Henrik
dc.contributor.authorSmåstuen, Milada Cvancarova
dc.contributor.authorMøller, Morten Hylander
dc.contributor.authorLarsson, Anders
dc.contributor.authorAslam, Tayyba Naz
dc.contributor.authorHofsø, Kristin
dc.contributor.authorPham, Tài
dc.contributor.authorFan, Eddy
dc.contributor.authorBellani, Giacomo
dc.contributor.authorLaffey, John G
dc.date.accessioned2024-07-11T10:50:09Z
dc.date.available2024-07-11T10:50:09Z
dc.date.issued2022-05-12
dc.identifier.pmid35398892
dc.identifier.doi10.1111/aas.14069
dc.identifier.urihttp://hdl.handle.net/10147/642125
dc.descriptionBackground: The "Large observational study to understand the global impact of severe acute respiratory failure" (LUNG SAFE) study described the worldwide epidemiology and management of patients with acute hypoxaemic respiratory failure (AHRF). Here, we present the Nordic subset of data from the LUNG SAFE cohort. Methods: We extracted LUNG SAFE data for adults fulfilling criteria for AHRF in intensive care units (ICU) in Denmark, Norway and Sweden, including demographics, co-morbidities, clinical assessment and management characteristics, 90-day survival and length-of-stay (LOS). We analysed ICU LOS with linear regression, and associations between risk factors and mortality were quantified using Cox regression. Results: We included 192 patients, with a median age of 64 years (IQR 55, 72), and a male-to-female ratio of 2:1. The majority had one or more co-morbidities, and clinicians identified pneumonia as the primary cause of respiratory failure in 56% and acute respiratory distress syndrome (ARDS) in 21%. Median ICU LOS and duration of invasive mechanical ventilation (IMV) were 5 and 3 days. Tidal volumes (TV) were frequently larger than that supported by evidence and IMV allowing for spontaneous ventilation was common. Younger age, co-morbidity, surgical admission and ARDS were associated with ICU LOS. Sixty-one patients (32%) were dead at 90 days. Age and a non-surgical cause of admission were associated with death. Conclusions: In this subset of LUNG SAFE, ARDS was often not recognised in patients with AHRF and management frequently deviated from evidence-based practices. ICU LOS was generally short, and mortality was attributable to known risk factors.en_US
dc.language.isoenen_US
dc.rights© 2022 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectLUNGSen_US
dc.subjectsevere acute respiratory failureen_US
dc.titlePatient characteristics, management and outcomes in a Nordic subset of the "large observational study to understand the global impact of severe acute respiratory failure" (LUNG SAFE) study.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn1399-6576
dc.identifier.journalActa anaesthesiologica Scandinavicaen_US
dc.source.journaltitleActa anaesthesiologica Scandinavica
dc.source.volume66
dc.source.issue6
dc.source.beginpage684
dc.source.endpage695
refterms.dateFOA2024-07-11T10:50:11Z
dc.source.countryEngland


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© 2022 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.
Except where otherwise noted, this item's license is described as © 2022 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.